Beetroot juice and exercise for patients with chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of beetroot extract supplementation combined with an exercise protocol on patients with chronic kidney disease (CKD). The study employs a randomized, double-blind, placebo-controlled design to assess both acute and chronic impacts of beetroot juice on inflammation and oxidative stress in CKD patients. Participants will undergo nutritional monitoring and exercise familiarization, followed by data collection on various health metrics. The goal is to determine if beetroot can improve health outcomes for CKD patients through its bioactive compounds.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with CKD undergoing conservative treatment (stages G3a-G4);
* Aged between 18 and 65 years old;
* Patients undergoing nutritional monitoring for more than 6 months.

Exclusion Criteria:

* Patients using catabolic drugs;
* Smokers
* Pregnant women;
* Using antibiotics and of proton pump inhibitors in the last 3 months;
* Antioxidant supplements and habitual intake of beetroot or nitrate supplement;
* Those who are clinically unstable (unstable angina, atrial fibrillation, significant cardiac arrhythmia and acute illness in the last month; and glycemic lability);
* Unable to exercise (amputation without prosthesis); musculoskeletal pain at rest or with minimal physical activity, inability to sit or walk without assistance, use of a walking device, dyspnea at rest or with light exertion;
* Those with autoimmune diseases and infectious diseases, cancer, liver disease and AIDS.
* Patients with parathormone (PTH) levels above 500pg/mL;
* Those who are allergic or intolerant to the components of the juice.
* Patients with any impediment to completing the proposed exercise protocol, such as due to travel or difficulty accessing the location where the research will be carried out.

Where it's running

• Denise Mafra
  Rio de Janeiro, Rio de Janeiro, Brazil Recruiting

Study contacts

• Principal investigator: Denise Mafra, PhD — Associate Professor - Universidade Federal Fluminense
• Study coordinator: Denise Mafra, PhD
• Email: dmafra30@gmail.com
• Phone: +5521985683003

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.