Beetroot juice and exercise for patients with chronic kidney disease
Effects of Beetroot Extract Supplementation Associated With an Exercise Protocol on Oxidative Stress, Inflammation, and Functional Capacity in Patients With Chronic Kidney Disease
This study is testing if drinking beetroot juice along with exercise can help improve health for people with chronic kidney disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Universidade Federal Fluminense Academic / other |
| Locations | 1 site (Rio de Janeiro, Rio de Janeiro) |
| Trial ID | NCT06286748 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of beetroot extract supplementation combined with an exercise protocol on patients with chronic kidney disease (CKD). The study employs a randomized, double-blind, placebo-controlled design to assess both acute and chronic impacts of beetroot juice on inflammation and oxidative stress in CKD patients. Participants will undergo nutritional monitoring and exercise familiarization, followed by data collection on various health metrics. The goal is to determine if beetroot can improve health outcomes for CKD patients through its bioactive compounds.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 with chronic kidney disease stages G3a-G4 who have been under nutritional monitoring for at least six months.
Not a fit: Patients with unstable health conditions, those unable to exercise, or those with certain comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the management of chronic kidney disease by reducing inflammation and oxidative stress, potentially improving patient outcomes.
How similar studies have performed: While the specific combination of beetroot supplementation and exercise in CKD patients is novel, previous studies have shown positive effects of dietary interventions and exercise on kidney health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with CKD undergoing conservative treatment (stages G3a-G4); * Aged between 18 and 65 years old; * Patients undergoing nutritional monitoring for more than 6 months. Exclusion Criteria: * Patients using catabolic drugs; * Smokers * Pregnant women; * Using antibiotics and of proton pump inhibitors in the last 3 months; * Antioxidant supplements and habitual intake of beetroot or nitrate supplement; * Those who are clinically unstable (unstable angina, atrial fibrillation, significant cardiac arrhythmia and acute illness in the last month; and glycemic lability); * Unable to exercise (amputation without prosthesis); musculoskeletal pain at rest or with minimal physical activity, inability to sit or walk without assistance, use of a walking device, dyspnea at rest or with light exertion; * Those with autoimmune diseases and infectious diseases, cancer, liver disease and AIDS. * Patients with parathormone (PTH) levels above 500pg/mL; * Those who are allergic or intolerant to the components of the juice. * Patients with any impediment to completing the proposed exercise protocol, such as due to travel or difficulty accessing the location where the research will be carried out.
Where this trial is running
Rio de Janeiro, Rio de Janeiro
- Denise Mafra — Rio de Janeiro, Rio de Janeiro, Brazil (Recruiting)
Study contacts
- Principal investigator: Denise Mafra, PhD — Associate Professor - Universidade Federal Fluminense
- Study coordinator: Denise Mafra, PhD
- Email: dmafra30@gmail.com
- Phone: +5521985683003
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.