Beetroot extract effects on blood pressure and muscle oxygen during exercise in older women with high blood pressure
Official title: Acute Effects of Beetroot Extract Supplementation on Blood Pressure, Oxidative Stress, and Muscle Oxygen Saturation in Hypertensive Older Women Submitted to an Aerobic Exercise Session
Run by São Paulo State University · NCT07444138 · Data updated 2026-11-12
This trial will test whether a beetroot supplement taken before exercise lowers blood pressure and improves muscle oxygen levels in women aged 60 to 70 with high blood pressure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years and up |
| Sex | Women only |
| Enrollment | 20 (estimated) |
| Sponsor | São Paulo State University Academic / other |
| Locations | 1 site (Bauru, São Paulo) |
| Status | Recruiting |
| Started | October 8, 2025 |
| Main results expected | June 2026 |
| Study ends | July 2026 |
| Registry record updated | March 2, 2026 |
| Trial ID | NCT07444138 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 60 to 70 with diagnosed hypertension who can perform the required aerobic exercise and do not have other cardiovascular disease, current smoking, or alcohol abuse.
✕Probably not a fit
People with significant cardiovascular disease, current smokers, those with alcohol abuse, men, or adults outside the 60–70 age range are unlikely to get relevant results from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind crossover study gives each participant both a nitrate-rich beetroot extract and a matched placebo in random order, with aerobic exercise and rest sessions to compare acute responses. Eligible women (60–70 years) with hypertension who can safely perform the exercise will complete a single supervised aerobic session after each supplement condition. Investigators will measure blood pressure responses, oxidative stress markers, and muscle oxygen saturation using near-infrared spectroscopy (NIRS) to capture immediate physiological effects. The focus is on whether a single dose of dietary nitrate can blunt exercise-related cardiovascular stress and improve muscle oxygenation in this group.
Why it matters
Potential benefit: If successful, the supplement could reduce exercise-related blood pressure spikes and improve muscle oxygenation, making exercise safer and more comfortable for older women with hypertension.
How similar studies have gone: Prior trials in adults have often shown that dietary nitrate from beetroot lowers blood pressure and can aid exercise performance, but evidence specifically in older hypertensive women during exercise is limited and mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female sex: Older women aged between 60 and 70 years. * Physical capability: Absence of health conditions that could compromise performance in the required physical exercise tests. Exclusion Criteria: * Smoking: Current smokers. * Alcohol use: History of alcohol abuse or excessive alcohol consumption. * Cardiovascular Disease: Diagnosis of cardiovascular diseases (other than the primary condition of hypertension).
Where it's running
-
São Paulo State University (UNESP)
Bauru, São Paulo, Brazil Recruiting
Study contacts
- Study coordinator: Anderson S Zago, Professor
- Email: anderson.zago@unesp.br
- Phone: +55 14 98199-9293
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.