Automatic facial phenotyping from 2D photos

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project reuses clinical frontal and profile facial photographs and associated clinical data from patients seen in medical genetics and maxillofacial/craniofacial surgery at Necker Hospital. Researchers will apply and train AI algorithms on these 2D images to automatically detect dysmorphic facial features linked to rare diseases. A control group of patients treated for non-dysmorphic maxillofacial conditions will provide comparative data. Patients who had prior facial or skull surgery before their first photo or who refuse data reuse are excluded.

Why it matters

Who can join: the full rules

The patient inclusion criteria are:

* Patients followed in medical genetics,
* Patients undergoing maxillofacial surgery, or craniofacial surgery as part of the management of a pathology, of genetic origin or not, associated with dysmorphism of the head and neck,
* Patients for whom frontal and profile facial photographs are taken as part of their treatment.

The inclusion criteria for control subjects are:

* Patients followed in maxillofacial surgery, for a disease other than a rare disease associated with dysmorphia in the head or neck: acute pathology (wound) or chronic (gynecomastia).
* Patients for whom frontal and profile facial photographs are taken as part of their treatment.

The criteria for non-inclusion of patients are:

* Patients who have undergone facial or skull surgery before the first photo was taken.
* Person subject to a judicial safeguard measure.
* People objecting to the reuse of their health data.

The criteria for non-inclusion of control subjects are:

* Pathologies affecting facial symmetry (dental cellulitis, displaced fractures).
* Patient followed for dysmorphic syndrome or in whom dysmorphic syndrome has been suspected.
* Person subject to a judicial safeguard measure.
* People objecting to the reuse of their health data.

Where it's running

• Necker - Hôpital des Enfants Malades
  Paris, France Recruiting

Study contacts

• Study coordinator: Yasmine Ainouz, MD
• Email: yasmine.ainouz@institutimagine.org
• Phone: +33 1 42 75 45 65

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.