Condition

Left Atrial Appendage Closure clinical trials and research

• 7Clinical trials
• 9Countries

Newest Left Atrial Appendage Closure clinical trials

All recruiting trials (7)

• Tailored lower‑intensity blood thinner plan after left atrial appendage closure to prevent stroke

  This project tests whether people with non‑valvular atrial fibrillation who get a left atrial appendage closure can stop blood thinners after taking low‑dose apixaban (2.5 mg twice daily) for 3 months, compared with people who stay on standard‑dose DOACs.

  Recruiting National Medical Research Center for Therapy and Preventive Medicine · Moscow · NCT07575867

• Agilis RF system to cross the atrial septum for left heart access

  This will test a radiofrequency transseptal device to help adults needing left atrial or left ventricular procedures safely cross the atrial septum.

  Recruiting at 3 sites Abbott Medical Devices · Jonesboro, Arkansas and 2 other locations · NCT07361445

• Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure in AF Patients

  In patients with atrial fibrillation who need both ablation and left atrial appendage closure, this study tests doing both procedures in a single intervention using FARAPULSE PFA and a WATCHMAN FLX device.

  Recruiting at 10 sites Boston Scientific Corporation · Aalst and 10 other locations · NCT07349121

• No blood-thinners versus aspirin after left atrial appendage closure

  This trial tests whether skipping antithrombotic drugs after left atrial appendage closure (using only 45 days of oral anticoagulant) is as safe and effective as taking aspirin for people with nonvalvular atrial fibrillation who are at high bleeding risk.

  Recruiting at 20 sites Phase 4 OCEAN-SHD Study Group · Nagoya, Aichi-ken and 20 other locations · NCT07125417

• Comparing LAAO and anticoagulation in stroke patients

  This study is testing if adding a procedure to close off a part of the heart can help stroke patients who are already taking blood thinners and still having strokes.

  Recruiting Hospital Clinic of Barcelona · Barcelona, Barcelona · NCT06869811

• Intracardiac versus transesophageal guidance for left atrial appendage closure

  This trial will test whether using intracardiac echocardiography (ICE) instead of transesophageal echocardiography (TEE) to guide left atrial appendage closure is safe and works well for people with non-valvular atrial fibrillation who want a non-drug option to reduce stroke risk.

  Recruiting Baylor Research Institute · Plano, Texas · NCT06348394

• Registry documenting left atrial appendage closure procedures in Austria

  This study is collecting information on patients with atrial fibrillation in Austria who have had a left atrial appendage closure procedure because they can't take blood thinners, to see how safe and effective the treatment is.

  Recruiting Medical University of Graz · Graz · NCT03409159

Related topics

Quick answers

How many Left Atrial Appendage Closure clinical trials are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Spain (2 trials), United States (2 trials), Belgium (1 trial), Croatia (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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