Assessing the safety and feasibility of upright positioning for patients with acute respiratory distress syndrome.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the feasibility and safety of a new positioning technique called verticalization for patients suffering from Acute Respiratory Distress Syndrome (ARDS). The study involves a cross-over design where patients will alternate between the traditional prone position and the new verticalization technique, which involves gradually raising the patient's bed to a 55° angle. The trial will monitor various clinical responses, including arterial blood gas measurements and chest ultrasounds, to assess the impact of these positioning techniques on patient outcomes. The goal is to determine if verticalization can improve oxygenation and reduce complications associated with the prone position.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Major patient \> 18 years of age
* ARDS patients with PaO2/FiO2 ratio \< 150 at any time within 24 hours prior to the screening visit
* Hemodynamically stable patient with mean arterial pressure (MAP) \> 65 mmHg maintained without vasopressor or with norepinephrine at a dosage of less than 0.5 µg/kg/min.
* Patient having already undergone at least 1 but less than 5 PP sessions
* Patient under continuous intravenous sedation (IVSE) or not responding to simple order.
* Written consent of support person or family.

Exclusion Criteria:

* Pregnant women (positive pregnancy test during screening)
* Breastfeeding women
* Protected Majors
* Body weight greater than 198 kg (bed load limit)
* Patient with one or two lower limbs amputated at the trans tibial or upper level
* Contraindication to standing (orthopedic fracture, neurological instability with the presence of an intracranial pressure sensor or an external ventricular shunt....)
* Deep venous thrombosis of the lower limbs with curative anticoagulation for less than 48 hours
* Hemodynamic instability (MAP \< 65 mm Hg) despite the use of norepinephrine at a dosage equal or greater than 0.5 µg/kg/min.
* Person under guardianship or trusteeship
* Non-beneficiary patient of a health insurance plan
* Moribund patient

Where it's running

• CHR d'ORLEANS
  Orléans, France Recruiting

Study contacts

• Principal investigator: Mai-ANh NAY, Dr — CHR Orléans
• Study coordinator: Aurélie DESPUJOLS
• Email: aurelie.despujols@chr-orleans.fr
• Phone: +33238744071

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Determining the best duration for patients with ARDS in the prone position

  This study is testing how long patients with Acute Respiratory Distress Syndrome should stay in a face-down position to see if it helps their breathing and reduces inflammation.

  Recruiting National Taiwan University Hospital · Taipei · NCT06827184

• Full-Course ECMO Pathway for Moderate-to-Severe ARDS

  This study tests a standardized, full-course ECMO management pathway to see if it improves care for adults with moderate-to-severe ARDS treated with VV-ECMO in real-world Chinese centers.

  Recruiting at 15 sites Southeast University, China · Beijing and 38 other locations · NCT07726953

• Height measurement methods to guide ventilator settings in ARDS

  We’re testing whether more precise height measurements change how researchers set lung-protective tidal volumes in adults with ARDS who are on a ventilator.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07595926

• Corticosteroids for a hyperinflammatory state in critical illness

  This trial tests whether methylprednisolone helps improve organ function and survival in adults with sepsis or ARDS who show a hyperinflammatory profile.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07511582

• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

  This project will follow adults with ARDS on mechanical ventilation to see how positive‑pressure breathing affects the right heart over time and how that relates to circulation.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT07450846

• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

  This trial tests whether IV umbilical‑cord mesenchymal stem cells, alone or with secretome, help adults with severe ARDS recover lung function and reduce inflammation.

  Recruiting Phase 1/2 PT. Prodia Stem Cell Indonesia · Jakarta Pusat, DKI Jakarta · NCT07439848

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.