Assessing muscle strength and thickness in critically ill patients on mechanical ventilation
Correlation Between Muscle Strength and Thickness in Critically Ill Patients: an Observational Prospective Study
This study is testing how muscle thickness and strength change in critically ill patients on mechanical ventilation to see if these measurements can help understand their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT06289244 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the relationship between muscle thickness and strength in critically ill patients who are undergoing prolonged mechanical ventilation in the ICU. Using bedside ultrasound, the study will measure the thickness of the diaphragm and quadriceps muscles at multiple time points during the patients' ICU stay. Muscle strength will be assessed using the Medical Research Council Score and a dynamometer for precise measurements. The study seeks to understand the variations in muscle thickness and strength in response to extended mechanical ventilation.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill patients aged 18 and older who are intubated and on mechanical ventilation for at least 48 hours.
Not a fit: Patients with contraindications to assessment, such as acute bleeding or preexisting neuromuscular diseases, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into muscle preservation strategies for critically ill patients, potentially improving their recovery outcomes.
How similar studies have performed: While the specific approach of this study is observational, similar studies assessing muscle strength and thickness in critically ill patients have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years; * Intubated patients on mechanical ventilation presumably for 48 hours; * Informed consent Exclusion Criteria: * Contraindication (absolute or relative) to assessment: acute bleeding, multiple fractures or trauma, spinal instability; * Hemodynamic instability during assessment; * ICU admission due to thoracic surgery, including lung transplant patients; * History of preexisting neuromuscular diseases; * History of preexisting functional impairment; * Pheripheral Neural disease; * Cervical spine injury;
Where this trial is running
Milan
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico — Milan, Italy (Recruiting)
Study contacts
- Principal investigator: Veronica Rossi, MSc — Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Study coordinator: Veronica Rossi, MSc
- Email: veronica.rossi@policlinico.mi.it
- Phone: +39 02 5503 4954
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.