Assessing immune changes in breast cancer patients after radiation therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the changes in immune cell levels in breast cancer patients following hypofractionated radiation therapy. The primary objective is to measure the percent change in immune infiltration at specific time points after radiation treatment. Secondary objectives include assessing DNA damage and examining immune signaling in cancer cells post-therapy. Patients will undergo tumor biopsies and blood sample collection before and after radiation to gather comprehensive data on immune responses and DNA damage.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients \>= 18 years of age with biopsy proven invasive breast cancer
* Breast cancer that appears to be superficially accessible to a tumor punch biopsy
* Patients thought to derive clinical benefit from palliative RT to the breast/chestwall
* In discussions with the medical oncologist, if clinically reasonable, systemic therapy will be held during RT

Exclusion Criteria:

* A history of prior radiation to the area requiring radiation for which the attending physician believes reirradiation could not be safely delivered
* Pregnancy
* Active usage of anticoagulant medications that are considered to pose an increased risk of tumor punch biopsies
* Receipt of immunotherapy or chemotherapy 7 days prior to start of RT

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Simona F Shaitelman, MD — M.D. Anderson Cancer Center
• Study coordinator: Simona F Shaitelman, MD
• Email: sfshaitelman@mdanderson.org
• Phone: (713) 563-8491

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.