Assessing heart energy metabolism in septic shock and chronic heart failure
Energy MEtabolism of Septic Heart.
This study is trying to see how the heart uses energy in people with septic shock and chronic heart failure to better understand their heart problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 32 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre de recherche du Centre hospitalier universitaire de Sherbrooke Academic / other |
| Locations | 1 site (Sherbrooke, Quebec) |
| Trial ID | NCT05202938 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the energy metabolism of the heart in patients experiencing septic shock and chronic heart failure. Using advanced imaging techniques such as positron emission tomography (PET) and ultrasound cardiography, the study will quantify how the heart selects and utilizes different energy substrates under these conditions. It will compare the metabolic profiles and functional status of patients with septic shock to those with acute on chronic heart failure, focusing on mitochondrial activity and cardiac efficiency. The findings could provide insights into the underlying mechanisms of heart dysfunction in these critical conditions.
Who should consider this trial
Good fit: Ideal candidates include hospitalized patients in intensive care units with septic shock or chronic heart failure.
Not a fit: Patients who are pediatric, moribund, or too unstable for imaging procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of heart dysfunction in patients with septic shock and chronic heart failure.
How similar studies have performed: While the approach of using PET scans to assess cardiac energy metabolism is established, the specific focus on septic shock and chronic heart failure in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients hospitalized in intensive care unit and coronary unit of the Sherbrooke hospital/CHUS. * Accepts healthy volunteers: 4 to 6 age- and sex-matched HV will be recruited and imaged at the end of the inclusion window for the assessment of cardiac energy tracer's uptake and as ref. controls. Exclusion Criteria: * Pediatric patients * Albumin allergy * Moribund patients * Patients too much unstable for the imaging procedure (clinical judgment) * Unavailable tracers, staff, PET scan in a maximum delay of 72 hours
Where this trial is running
Sherbrooke, Quebec
- Chus — Sherbrooke, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Olivier Lesur, MD PhD — Centre de recherche du Centre hospitalier universitaire de Sherbrooke
- Study coordinator: Olivier Lesur, MD PhD
- Email: olivier.lesur@usherbrooke.ca
- Phone: 819-346-1110
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.