Assessing heart disease risk in kidney transplant patients using CT scans
Official title: Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
Run by University of Edinburgh · NCT06234410 · Data updated 2026-11-12
This study is testing if a special type of CT scan can help find out which kidney transplant patients are at higher risk for heart disease before their surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 332 (estimated) |
| Sponsor | University of Edinburgh Academic / other |
| Locations | 5 sites (Edinburgh, Lothian and 4 other locations) |
| Status | Recruiting |
| Started | January 24, 2024 |
| Main results expected | January 2032 |
| Study ends | January 2032 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT06234410 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 16 and over with kidney failure who are on the waitlist for a kidney transplant.
✕Probably not a fit
Patients with contraindications to CT scanning or those being considered for simultaneous multi-organ transplants may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the effectiveness of computed tomography coronary angiography (CTCA) in identifying patients at high risk for cardiovascular disease before they undergo kidney transplantation. Cardiovascular disease is a leading complication for patients with kidney failure, and current assessment methods do not adequately identify those at greatest risk. By utilizing CTCA, the study seeks to improve risk stratification and potentially enhance patient outcomes following transplantation. The study will include patients aged 16 and over who are on the waitlist for a kidney transplant and able to provide informed consent.
Why it matters
Potential benefit: If successful, this study could lead to better identification of high-risk patients, ultimately improving their outcomes after kidney transplantation.
How similar studies have gone: Previous studies have shown that CTCA can effectively identify cardiovascular risk in patients with normal kidney function, suggesting potential for success in this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Has kidney failure and is on the waitlist for a kidney transplant * Age 16 years and over * Able to give informed consent Exclusion Criteria: * Contraindication to CT scanning, including contrast allergy * Patients being considered for a simultaneous kidney-pancreas, kidney-liver and/or kidney-islet transplantation * Inability to give informed consent
Where it's running
-
Royal Infirmary of Edinburgh
Edinburgh, Lothian, United Kingdom Recruiting -
Queen Elizabeth Hospital
Glasgow, United Kingdom Recruiting -
Imperial College Healthcare NHS Trust
London, United Kingdom Recruiting -
University Hospitals Plymouth NHS Trust
Plymouth, United Kingdom Recruiting -
Sheffield Teaching Hospitals NHS Trust
Sheffield, United Kingdom Recruiting
Study contacts
- Principal investigator: Neeraj Dhaun, MBChB — University of Edinburgh
- Study coordinator: Gavin B Chapman, MBChB
- Email: gchapma2@ed.ac.uk
- Phone: 00447713349318
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.