Assessing genetic factors in specific language and learning disorders
Official title: Study of the Value of Trio Exome Sequencing in the Etiological Assessment of Specific Non-syndromic Language and Learning Disorders
Run by Centre Hospitalier Universitaire Dijon · NCT05939739 · Data updated 2026-11-12
This study is testing whether looking at the genes of children with severe learning disorders and their parents can help us understand and better manage specific language and learning disorders.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 3 Years to 40 Years |
| Sex | All |
| Enrollment | 101 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | August 7, 2023 |
| Main results expected | January 2027 |
| Study ends | January 2027 |
| Registry record updated | June 17, 2025 |
| Trial ID | NCT05939739 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children aged 3 to 40 with severe learning disorders requiring in-school help or intensive rehabilitation.
✕Probably not a fit
Patients with confirmed intellectual disabilities or obvious syndromic diagnoses may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the role of trio exome sequencing in understanding the genetic basis of specific language and learning disorders (SLLD) in children. It focuses on children aged 3 to 40 who exhibit severe learning disorders and have not previously undergone genetic testing. The study involves collecting blood samples from the affected child and their biological parents to analyze genetic variations that may contribute to these disorders. The findings aim to improve diagnosis and management strategies for SLLD.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and targeted interventions for children with specific language and learning disorders.
How similar studies have gone: Other studies have shown promise in using genetic testing to understand learning disorders, suggesting this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Index case suffering from one or more severe learning disorders (requiring in-school help or intensive rehabilitation), justified by neuropsychological and/or speech therapy and/or occupational therapy assessments, reviewed by experts and supplemented if necessary within the framework of the study, and not yet having undergone genetic testing. * Index case aged 3 to 40 years * Sample may be taken from index case and 2 known biological parents * Consent signed by the parents and by the index case if major * Index case and parents covered by national health insurance Exclusion Criteria: * Index case and parents have a condition which, in the opinion of the investigator, would contraindicate the subject's participation in the study. * Intellectual disability confirmed by neuropsychological testing or strongly suspected clinically in the index case and/or his/her parents * Obvious syndromic diagnosis (syndrome or antecedents having definitely led to a developmental disorder) * Persons deprived of liberty by judicial or administrative decision, * Adults under guardianship, * Persons residing in a health or social establishment * Patients in critical situations * Pregnant, parturient or nursing women * Previous array CGH and/or Fragile X testing or any other targeted genetic examination (except standard karyotype).
Where it's running
-
CHU Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Julian DELANNE
- Email: julian.delanne@chu-dijon.fr
- Phone: 03 80 29 53 13
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.