Assessing fluid responsiveness in patients with impaired consciousness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of various methods for assessing fluid responsiveness in patients experiencing hypotension and cognitive impairment. It employs tests such as evaluating the inferior vena cava's diameter, passive leg raising (PLR), and fluid challenge (FC) to determine how well patients respond to infusion therapy. The study aims to address the limitations of traditional static measurements like central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP), particularly in patients with altered consciousness levels. By focusing on more accessible and cost-effective methods, the research seeks to improve management strategies for hypotension in intensive care settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Hospitalization in an intensive care unit
* Level of consciousness on the FOUR scale ≤ 12 points
* Planned infusion therapy
* Presence of a central venous catheter or direct indication for catheterization
* The decision of the medical council to include the patient in the study

Exclusion Criteria:

* Pulmonary edema
* Absence of one or both lower extremities
* Chronic kidney disease according to KDIGO classification ≥ stage 3b
* Acute kidney injury grade 3
* Documented or suspected increased intracranial pressure (cerebral edema, brain compression, hydrocephalus, etc.).
* Presence of mitral valve regurgitation \> grade 1
* Presence of aortic valve regurgitation \> grade 1
* Patients previously enrolled in the "COMPASS" study in the period of 12 preceding hours

Where it's running

• Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
  Moscow, Russia Recruiting

Study contacts

• Principal investigator: Valery Likhvantsev, PhD — Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
• Study coordinator: Valery Likhvantsev, PhD
• Email: lik0704@gmail.com
• Phone: +79036235982

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.