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Assessing adherence to heart disease prevention guidelines

BRING-UP Prevention

Heart Care Foundation · NCT06275113

This study looks at how well patients with heart-related issues follow prevention guidelines and tests two educational programs to see if they can help improve adherence over six months.

Quick facts

Study typeObservational
Enrollment6000 (estimated)
Ages18 Years and up
SexAll
SponsorHeart Care Foundation (other)
Locations196 sites (Canicattì, AG and 195 other locations)
Trial IDNCT06275113 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate how well patients with documented athero-thrombotic events, such as coronary artery disease, cerebrovascular disease, and peripheral artery disease, adhere to established guidelines for secondary prevention. The study involves two educational interventions to discuss these guidelines, followed by data collection on patient adherence over a 6-month period. It will analyze the reasons for non-adherence and assess the impact of educational efforts on improving patient outcomes. The study is conducted across multiple cardiology centers in Italy.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with documented coronary artery disease, cerebrovascular disease, or peripheral artery disease.

Not a fit: Patients with active neoplasia or severe diseases that compromise short to medium-term life expectancy may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance adherence to prevention guidelines, potentially reducing the recurrence of cardiovascular events in patients.

How similar studies have performed: Other studies have shown success in improving patient outcomes through educational interventions focused on guideline adherence, suggesting this approach may be effective.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Both sexes at birth, age ≥18 years

At least one of the following clinical conditions:

* Documented CAD defined as:

  * Prior Acute Coronary Syndrom (ACS)
  * Prior Coronary Artery Bypass Graft (CABG)
  * Prior Percutaneous Coronary Intervention (PCI)
* Documented PAD (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease, Ankle Brachial Index (ABI)\<90).
* Documented CVD: Ischemic stroke, previous carotid vascular interventions.
* Signed informed consent.

Exclusion Criteria:

* Active neoplasia or very severe disease compromising short-medium term life expectancy.
* Participation in interventional studies.
* Patients already enrolled into the study from another participating center or in the previous enrolling phase.

Where this trial is running

Canicattì, AG and 195 other locations

+146 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Ischemic Heart Disease, Cerebrovascular Disorders, Peripheral Arterial Disease

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.