Clinical trial Recruiting at 1 site Interventional Ages 8 to 18

Asiaticoside as an intracanal medicine to help revascularization in immature teeth

Official title: Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process : Randomized Clinical Trial

Run by Mansoura University · NCT07802340 · Data updated 2026-11-12

This trial tests whether Asiaticoside as an intracanal medication can improve revascularization in immature permanent teeth with pulp necrosis compared to calcium hydroxide.

More Pulp Necrosis trials

Quick facts

Study typeInterventional
Ages8 Years to 18 Years
SexAll
Enrollment20 (estimated)
SponsorMansoura University
Academic / other
Locations1 site (Al Mansurah)
StatusRecruiting
StartedOctober 1, 2026
Main results expectedFebruary 2027
Study endsFebruary 2028
Registry record updatedSeptember 23, 2026
Trial IDNCT07802340 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are generally healthy individuals with immature permanent anterior teeth with necrotic pulp and open apex requiring intracanal medication.

Probably not a fit

Patients with root fractures, resorption, or inability to cooperate, or those needing a post and core may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines Asiaticoside as an intracanal medication for revascularization in immature permanent teeth with necrotic pulp. Participants receive Asiaticoside-based medication and are compared to the standard calcium hydroxide approach. The study focuses on clinical and radiographic outcomes to determine feasibility and potential benefits. Eligible patients are generally healthy and have necrotic pulp with an open apex in anterior teeth. The trial is conducted at Mansoura University in Egypt and does not specify a control arm beyond the active comparator.

Why it matters

Potential benefit: If successful, patients may experience improved success of revascularization and better preservation of immature teeth.

How similar studies have gone: Previous work in similar approaches suggests potential for intracanal medications to influence revascularization outcomes, though the Asiaticoside-specific evidence is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Both gender
* patients having permanent anterior teeth with necrotic pulp and immature apex
* Good general health
* pulp space not needed for post and core

Exclusion Criteria:

* Radiographic identification of root fracture or abnormality
* Uncooperative patients
* Root resorption (internal or external)

Where it's running

  • Mansoura University
    Al Mansurah, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.