Asiaticoside as an intracanal medicine to help revascularization in immature teeth
Official title: Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process : Randomized Clinical Trial
Run by Mansoura University · NCT07802340 · Data updated 2026-11-12
This trial tests whether Asiaticoside as an intracanal medication can improve revascularization in immature permanent teeth with pulp necrosis compared to calcium hydroxide.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 8 Years to 18 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah) |
| Status | Recruiting |
| Started | October 1, 2026 |
| Main results expected | February 2027 |
| Study ends | February 2028 |
| Registry record updated | September 23, 2026 |
| Trial ID | NCT07802340 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are generally healthy individuals with immature permanent anterior teeth with necrotic pulp and open apex requiring intracanal medication.
✕Probably not a fit
Patients with root fractures, resorption, or inability to cooperate, or those needing a post and core may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study examines Asiaticoside as an intracanal medication for revascularization in immature permanent teeth with necrotic pulp. Participants receive Asiaticoside-based medication and are compared to the standard calcium hydroxide approach. The study focuses on clinical and radiographic outcomes to determine feasibility and potential benefits. Eligible patients are generally healthy and have necrotic pulp with an open apex in anterior teeth. The trial is conducted at Mansoura University in Egypt and does not specify a control arm beyond the active comparator.
Why it matters
Potential benefit: If successful, patients may experience improved success of revascularization and better preservation of immature teeth.
How similar studies have gone: Previous work in similar approaches suggests potential for intracanal medications to influence revascularization outcomes, though the Asiaticoside-specific evidence is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Both gender * patients having permanent anterior teeth with necrotic pulp and immature apex * Good general health * pulp space not needed for post and core Exclusion Criteria: * Radiographic identification of root fracture or abnormality * Uncooperative patients * Root resorption (internal or external)
Where it's running
-
Mansoura University
Al Mansurah, Egypt Recruiting
Study contacts
- Study coordinator: Maha Baher Hassan
- Email: Mahabaher23@gmail.com
- Phone: 01007987417
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.