Intracanal Medications for Postoperative Pain After Endodontic Treatment in Necrotic Teeth
Official title: Evaluation of Postoperative Pain After Using Ibuprofen, Nitrofurantoin, or Calcium Hydroxide as Intracanal Medicaments in Root Canal Treatment of Necrotic Mandibular Posterior Teeth. A Randomized Controlled Trial
Run by Cairo University · NCT07603934 · Data updated 2026-11-12
This trial tests whether ibuprofen, nitrofurantoin, or calcium hydroxide inside the tooth can reduce postoperative pain after root canal treatment in adults with dead (necrotic) lower back teeth.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 111 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | February 15, 2027 |
| Study ends | March 15, 2027 |
| Registry record updated | July 21, 2026 |
| Trial ID | NCT07603934 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with necrotic pulps undergoing two-visit endodontic treatment and able to understand pain scales.
✕Probably not a fit
Patients with allergies to any of the medications, those who recently used pain meds, or with multiple symptomatic mandibular teeth in the same quadrant may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In adults with necrotic pulps in mandibular posterior teeth, participants are randomly assigned to receive ibuprofen, nitrofurantoin, or calcium hydroxide as intracanal medications during endodontic treatment. The study uses a double-blind, parallel-arm design with 1:1:1 allocation to compare pain outcomes after treatment. Pain is measured with standardized scales at predefined postoperative times to determine if one medication reduces pain more effectively. The trial is conducted in outpatient endodontics clinics in Cairo, Egypt, with three collaborating universities and a lead sponsor.
Why it matters
Potential benefit: If successful, patients may experience less postoperative pain after root canal treatment with one of the tested intracanal medications.
How similar studies have gone: Previous research has explored intracanal medications, but direct comparisons among ibuprofen, nitrofurantoin, and calcium hydroxide in this context are less common.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with necrotic pulps. 2. Adult, healthy patients, older than 18 years old 3. Males and females. 4. Patient with the ability to understand and use pain scales. 5. Patient who accepts enroll to the study. Exclusion Criteria: 1. Patients' allergies or any other contraindication to any of the medications used. 2. Pregnant and lactating females. 3. Patients have been taking pain medication 12 hours earlier. 4. Patients who have more than one symptomatic mandibular tooth in the same quadrant. 5. Patients with contributory medical history (ASA\>II).
Where it's running
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Faculty of Oral and Dental Medicine, Egyptian Russian University
Cairo, Cairo Governorate, Egypt Recruiting
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.