Appetite and blood sugar responses to plant versus animal protein meals in women with PCOS.
Official title: Comparative Meal Response to Plant vs. Animal Protein in Women With PCOS
Run by University of Arkansas, Fayetteville · NCT07142603 · Data updated 2026-11-12
This test sees if meals made with plant protein versus animal protein change blood sugar, insulin, and appetite in women with PCOS.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 30 (estimated) |
| Sponsor | University of Arkansas, Fayetteville Academic / other |
| Locations | 1 site (Fayetteville, Arkansas) |
| Status | Recruiting |
| Started | August 18, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | September 2, 2025 |
| Trial ID | NCT07142603 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women 18–50 years old with a confirmed diagnosis of PCOS, BMI 18.5–35 kg/m2, stable weight for at least three months, not taking metabolic medications, and willing to eat both plant- and animal-based test meals.
✕Probably not a fit
People with diagnosed diabetes, active smokers or marijuana users, those taking medications that affect glucose or appetite (e.g., metformin or GLP-1 agonists), or those with incompatible food allergies are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Women with PCOS will consume matched meals containing either plant-based or animal-based protein on separate clinic visits in a crossover design, with each participant eating both meal types. Investigators will measure postprandial glucose, insulin, and appetite-regulating hormones as well as subjective satiety for several hours after each meal. Eligible participants are women age 18–50 with confirmed PCOS and a BMI of 18.5–35 kg/m2 who are weight-stable and not taking medications that affect metabolism. The protocol excludes people with diabetes, incompatible dietary restrictions, or use of nicotine or marijuana products.
Why it matters
Potential benefit: If successful, results could help tailor dietary protein recommendations to improve post-meal blood sugar control and appetite management in women with PCOS.
How similar studies have gone: Prior studies in healthy populations show protein source can affect postprandial glycemia and satiety, but direct comparisons in women with PCOS are limited, so this approach is somewhat supported but still novel for this group.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Females ages 18-50 years * Confirmed diagnosis of PCOS * Body mass index (BMI) between 18.5 and 35 kg/m2 * Stable body weight for at least 3 months (+ 5 pounds) * Willingness to consume both plant- and animal-based protein meals Exclusion Criteria: * Smoking or use of nicotine products * Smoking or use of marijuana products * Food allergies or dietary restrictions incompatible with test meals * Diagnosed diabetes (type 1 or 2) * Use of medications that interfere with study outcomes (e.g., metformin, GLP-1 agonists, etc.)
Where it's running
-
Center for Human Nutrition
Fayetteville, Arkansas, United States Recruiting
Study contacts
- Principal investigator: Jamie I Baum, PhD — University of Arkansas, Fayetteville
- Study coordinator: Jamie I Baum, PhD
- Email: baum@uark.edu
- Phone: 479-575-4474
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using LC-MS/MS to profile androgens for PCOS diagnosis
This study tests whether LC-MS/MS measurement of androgen profiles can help diagnose PCOS in women compared with healthy controls.
-
Brown adipose tissue responses in PCOS with infrared thermography and inositol
This study tests whether brown fat activity, measured by infrared skin temperature and UCP-1 levels, differs among women with PCOS (normal weight or overweight/obese) and healthy controls, and whether 12 weeks of inositol changes those responses in overweight/obese PCOS participants.
-
Risk tool for blood-clotting problems in adolescents and women with PCOS
This project will try to build a risk model to spot decreased protein C or S and other clotting abnormalities in females aged 14–45 who have PCOS.
-
Polycystic Ovary Syndrome in Type 1 Diabetes
This study tests whether women with type 1 diabetes and PCOS differ from other groups in factors that drive androgen excess and what that means for health.
-
PPOS versus GnRH antagonist IVF protocols for women with PCOS
This trial will test whether a progestin-primed ovarian stimulation (PPOS) protocol or a GnRH antagonist protocol gives better IVF outcomes for women aged 18–40 with PCOS.
-
Detailed health profiling for people with PCOS
This effort will collect clinical, hormonal (including AMH), and imaging information from adult women seen at Strasbourg University Hospital with suspected or confirmed PCOS to try to better define PCOS types.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.