Appetite and blood sugar responses to plant versus animal protein meals in women with PCOS.
Comparative Meal Response to Plant vs. Animal Protein in Women With PCOS
This test sees if meals made with plant protein versus animal protein change blood sugar, insulin, and appetite in women with PCOS.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | University of Arkansas, Fayetteville Academic / other |
| Locations | 1 site (Fayetteville, Arkansas) |
| Trial ID | NCT07142603 on ClinicalTrials.gov |
What this trial studies
Women with PCOS will consume matched meals containing either plant-based or animal-based protein on separate clinic visits in a crossover design, with each participant eating both meal types. Investigators will measure postprandial glucose, insulin, and appetite-regulating hormones as well as subjective satiety for several hours after each meal. Eligible participants are women age 18–50 with confirmed PCOS and a BMI of 18.5–35 kg/m2 who are weight-stable and not taking medications that affect metabolism. The protocol excludes people with diabetes, incompatible dietary restrictions, or use of nicotine or marijuana products.
Who should consider this trial
Good fit: Ideal candidates are women 18–50 years old with a confirmed diagnosis of PCOS, BMI 18.5–35 kg/m2, stable weight for at least three months, not taking metabolic medications, and willing to eat both plant- and animal-based test meals.
Not a fit: People with diagnosed diabetes, active smokers or marijuana users, those taking medications that affect glucose or appetite (e.g., metformin or GLP-1 agonists), or those with incompatible food allergies are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, results could help tailor dietary protein recommendations to improve post-meal blood sugar control and appetite management in women with PCOS.
How similar studies have performed: Prior studies in healthy populations show protein source can affect postprandial glycemia and satiety, but direct comparisons in women with PCOS are limited, so this approach is somewhat supported but still novel for this group.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Females ages 18-50 years * Confirmed diagnosis of PCOS * Body mass index (BMI) between 18.5 and 35 kg/m2 * Stable body weight for at least 3 months (+ 5 pounds) * Willingness to consume both plant- and animal-based protein meals Exclusion Criteria: * Smoking or use of nicotine products * Smoking or use of marijuana products * Food allergies or dietary restrictions incompatible with test meals * Diagnosed diabetes (type 1 or 2) * Use of medications that interfere with study outcomes (e.g., metformin, GLP-1 agonists, etc.)
Where this trial is running
Fayetteville, Arkansas
- Center for Human Nutrition — Fayetteville, Arkansas, United States (Recruiting)
Study contacts
- Principal investigator: Jamie I Baum, PhD — University of Arkansas, Fayetteville
- Study coordinator: Jamie I Baum, PhD
- Email: baum@uark.edu
- Phone: 479-575-4474
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.