Aortic stenosis prognosis and outcomes after TAVI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study will enroll 300 patients planned for TAVI at Sahlgrenska University Hospital. It will collect clinical data, imaging (UCG, ECG, brain MRI, cardiac MRI, and CT), and blood tests before and after TAVI at specified intervals, plus quality-of-life measures. The goal is to describe prognosis, risk factors, and outcomes, including imaging markers of remodeling and microembolism. Follow-up includes visits up to one year and annually thereafter to track events and status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient with clinical indication for aortic valve replacement and scheduled for TAVI
* Patient willing and able to provide signed informed consent

Exclusion Criteria:

* Inability to provide informed consent Additional exclusion criteria for MRI
* Estimated glomerular filtration rate \<30 ml/kg/min (MRI without contrast can be performed )
* Claustrophobia or inability to tolerate confined spaces.
* Non-compatible metal device present in body
* Any other contra-indications for MRI as per local guidelines Additional exclusion criteria for the CT substudy
* Estimated glomerular filtration rate \<30 ml/kg/min (CT without contrast can be performed)

Where it's running

• Departement of Cardiology,
  Gothenburg, Sweden Recruiting
• Departement of Cardiology
  Gothenburg, Sweden Recruiting

Study contacts

• Study coordinator: Oskar Angerås, MD, PhD
• Email: oskar.angeras@vgregion.se
• Phone: +46 313421000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  This study tries to see if clinical measures and cardiopulmonary exercise testing can predict which adults with severe aortic stenosis will have improved physical fitness after transfemoral TAVI.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.