Finger photoacoustic arterial waveform monitoring for aortic valve disease and healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll adults aged 18–80 including patients with clinically diagnosed aortic stenosis, aortic regurgitation, and healthy controls. Participants will place a finger into a photoacoustic imaging device while arterial pulse waveform data are recorded noninvasively in real time. Signal-processing algorithms will extract waveform features and compare them across disease groups and severity levels. The goal is to determine whether waveform characteristics from the finger reflect valve disease presence and severity without invasive procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-80 years
* Able to provide informed consent
* For AR group: clinically diagnosed aortic regurgitation
* For AS group: clinically diagnosed aortic stenosis
* For healthy controls: no history of cardiovascular disease
* Able to undergo finger arterial waveform measurement

Exclusion Criteria:

* History of recent cardiac surgery or intervention (\<6 months)
* Hand disorders affecting finger mobility (e.g., arthritis)
* Pregnant or breastfeeding women
* Participation in other studies affecting arterial waveform
* Unable to understand or comply with study procedures

Where it's running

• the First Affiliated Hospital of University of Science and Technology of China
  Hefei, Anhui, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.