Finger photoacoustic arterial waveform monitoring for aortic valve disease and healthy adults
A Study on Noninvasive Real-Time Arterial Pressure Waveform Analysis for the Detection and Evaluation of Cardiovascular Diseases
This project will test whether a finger-based photoacoustic device can capture arterial pulse waveforms and help identify aortic stenosis, aortic regurgitation, or normal heart function in adults.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Anhui Provincial Cancer Hospital Academic / other |
| Locations | 1 site (Hefei, Anhui) |
| Trial ID | NCT07350629 on ClinicalTrials.gov |
What this trial studies
This observational study will enroll adults aged 18–80 including patients with clinically diagnosed aortic stenosis, aortic regurgitation, and healthy controls. Participants will place a finger into a photoacoustic imaging device while arterial pulse waveform data are recorded noninvasively in real time. Signal-processing algorithms will extract waveform features and compare them across disease groups and severity levels. The goal is to determine whether waveform characteristics from the finger reflect valve disease presence and severity without invasive procedures.
Who should consider this trial
Good fit: Adults age 18–80 with clinically diagnosed aortic stenosis or aortic regurgitation, or healthy adults without cardiovascular disease, who can provide consent and tolerate finger waveform measurement are ideal candidates.
Not a fit: Patients with recent cardiac surgery or intervention within six months, hand disorders that prevent finger placement, pregnant or breastfeeding women, or those unable to comply with procedures are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the approach could provide a quick, noninvasive way to detect or monitor aortic valve disease using finger pulse recordings.
How similar studies have performed: Pulse-waveform analysis with photoplethysmography has prior clinical use, but using finger photoacoustic imaging for arterial waveform capture is an emerging approach with limited clinical validation to date.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-80 years * Able to provide informed consent * For AR group: clinically diagnosed aortic regurgitation * For AS group: clinically diagnosed aortic stenosis * For healthy controls: no history of cardiovascular disease * Able to undergo finger arterial waveform measurement Exclusion Criteria: * History of recent cardiac surgery or intervention (\<6 months) * Hand disorders affecting finger mobility (e.g., arthritis) * Pregnant or breastfeeding women * Participation in other studies affecting arterial waveform * Unable to understand or comply with study procedures
Where this trial is running
Hefei, Anhui
- the First Affiliated Hospital of University of Science and Technology of China — Hefei, Anhui, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.