Anodal tDCS plus virtual-reality exergaming for thinking problems in people with multiple sclerosis.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a double-blind, randomized, controlled study enrolling 80 people with multiple sclerosis and cognitive impairment, split into an experimental group and a sham-control group. All participants complete ten one-hour exergaming (non-immersive VR) sessions over two weeks, while the experimental group receives simultaneous anodal tDCS over the left dorsolateral prefrontal cortex and the control group receives sham stimulation. The anodal electrode is placed over the left DLPFC and the reference electrode over the right shoulder using a portable constant-current stimulator. Outcomes focus on changes in cognitive performance and related symptoms such as fatigue and quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. MS diagnosis according to McDonald's criteria (McDonald 2017);
2. age between 18 and 60 (to avoid participants with possible CI due to aging); 3) disability score ≤7.5 at the Expanded Disability Status Scale (EDSS, Kurtzke 1983).

Exclusion Criteria:

1. subjects affected by major psychiatric disorders
2. epilepsy
3. previous brain surgery
4. MS relapse requiring steroid therapy in the previous two months
5. bilateral visual acuity \< 6/10

Where it's running

• Azienda Sanitaria Genovese
  Genova, Italy, Italy Recruiting
• Ospedale Policlinico San Martino - IRCCS
  Genova, Italy, Italy Recruiting
• Italian multiple sclerosis foundation
  Genova, Italy, Italy Recruiting

Study contacts

• Principal investigator: Laura Mori, MD, PhD — Ospedale Policlinico San Martino IRCCS
• Study coordinator: Laura Mori, MD, PhD
• Email: laura.mori@hsanmartino.it
• Phone: *39 010 555 5645

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.