Analyzing muscle mass changes in head and neck cancer patients after exercise training
Official title: (Health Promotion) Skeletal Muscle Mass Changes on Images for Prediction of Prognosis After Exercise Training in Head and Neck Cancer Patients
Run by Chang Gung Memorial Hospital · NCT06666881 · Data updated 2026-11-12
This study is testing if exercise training can help head and neck cancer patients gain muscle mass after treatment and if those changes can give clues about their recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 280 (estimated) |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (New Taipei City) |
| Status | Recruiting |
| Started | June 6, 2023 |
| Main results expected | September 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT06666881 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 20 and older with squamous cell carcinoma requiring concurrent chemoradiotherapy and an ECOG performance status of less than 2.
✕Probably not a fit
Patients with an ECOG performance status of 2 or higher, those intolerant to basic exercise training, or with concurrent medical conditions that may be aggravated by exercise will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project is a prospective study involving 60 participants diagnosed with head and neck cancer, divided into experimental and control groups. The study aims to evaluate changes in skeletal muscle mass through imaging techniques after a regimen of exercise training following concurrent chemoradiotherapy. Participants will undergo dual energy X-ray absorptiometry (DXA) and blood tests to assess systemic inflammatory markers before and after the exercise intervention. The goal is to determine if these changes can predict the prognosis of head and neck cancer.
Why it matters
Potential benefit: If successful, this study could provide insights into how exercise training impacts muscle mass and prognosis in head and neck cancer patients.
How similar studies have gone: While similar studies have explored the effects of exercise on cancer patients, this specific approach focusing on muscle mass changes and inflammatory markers in head and neck cancer is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥20 2. Pathology:Squamous cell carcinoma 3. Need CCRT treatment 4. ECOG PS\<2 5. Agree with blood drawing, exercise training, and all the procedures in the trial. Exclusion Criteria: 1. ECOG PS≥2 2. Participants with intolerance basic exercise training, or without CCRT treatment 3. Mental illness or any medical illness or concurrent illness that may be aggravated by exercise training or unmanageable 4. Any medical condition that unsuitable for exercise training 5. refure to do the trial procedures: exercise training, blood drawing and all the procedures in the trial. 6. can't get the data for the whole-body computed tomography
Where it's running
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New Taipei City TuCheng Hospital
New Taipei City, Taiwan Recruiting
Study contacts
- Study coordinator: Shao-Chung Wang, PhD
- Email: seanscwang@cgmh.org.tw
- Phone: 0978835190
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.