Analyzing muscle mass changes in head and neck cancer patients after exercise training
(Health Promotion) Skeletal Muscle Mass Changes on Images for Prediction of Prognosis After Exercise Training in Head and Neck Cancer Patients
This study is testing if exercise training can help head and neck cancer patients gain muscle mass after treatment and if those changes can give clues about their recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (New Taipei City) |
| Trial ID | NCT06666881 on ClinicalTrials.gov |
What this trial studies
This project is a prospective study involving 60 participants diagnosed with head and neck cancer, divided into experimental and control groups. The study aims to evaluate changes in skeletal muscle mass through imaging techniques after a regimen of exercise training following concurrent chemoradiotherapy. Participants will undergo dual energy X-ray absorptiometry (DXA) and blood tests to assess systemic inflammatory markers before and after the exercise intervention. The goal is to determine if these changes can predict the prognosis of head and neck cancer.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 and older with squamous cell carcinoma requiring concurrent chemoradiotherapy and an ECOG performance status of less than 2.
Not a fit: Patients with an ECOG performance status of 2 or higher, those intolerant to basic exercise training, or with concurrent medical conditions that may be aggravated by exercise will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how exercise training impacts muscle mass and prognosis in head and neck cancer patients.
How similar studies have performed: While similar studies have explored the effects of exercise on cancer patients, this specific approach focusing on muscle mass changes and inflammatory markers in head and neck cancer is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥20 2. Pathology:Squamous cell carcinoma 3. Need CCRT treatment 4. ECOG PS\<2 5. Agree with blood drawing, exercise training, and all the procedures in the trial. Exclusion Criteria: 1. ECOG PS≥2 2. Participants with intolerance basic exercise training, or without CCRT treatment 3. Mental illness or any medical illness or concurrent illness that may be aggravated by exercise training or unmanageable 4. Any medical condition that unsuitable for exercise training 5. refure to do the trial procedures: exercise training, blood drawing and all the procedures in the trial. 6. can't get the data for the whole-body computed tomography
Where this trial is running
New Taipei City
- New Taipei City TuCheng Hospital — New Taipei City, Taiwan (Recruiting)
Study contacts
- Study coordinator: Shao-Chung Wang, PhD
- Email: seanscwang@cgmh.org.tw
- Phone: 0978835190
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.