Analyzing kidney injury risks during controlled low blood pressure anesthesia in jaw surgery
Incidence and Risk Factors Analysis of Acute Kidney Injury (AKI) After Intentional Hypotensive Anesthesia in Orthognathic Surgery Patients Following Enhanced Recovery After Surgery (ERAS) Guidelines
This study is testing if using low blood pressure during jaw surgery can help prevent kidney injury in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital Academic / other |
| Locations | 1 site (Kaohsiung City, Sanmin Dist) |
| Trial ID | NCT06259760 on ClinicalTrials.gov |
What this trial studies
This project investigates the effects of intentional hypotensive management using nitroglycerin during general anesthesia in patients undergoing orthognathic surgery. The study involves monitoring blood biochemical and urine parameters throughout the surgical procedure to assess renal function and identify early risk factors for acute kidney injury (AKI). By recognizing these factors early, the research aims to implement intervention strategies that could prevent postoperative AKI, contributing to Enhanced Recovery After Surgery (ERAS) goals for improved patient recovery.
Who should consider this trial
Good fit: Ideal candidates are patients classified as ASA class I to II who are undergoing oro-maxillo-facial surgery and have unlimited mouth opening.
Not a fit: Patients with chronic renal insufficiency, significant obesity, or other specified comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help prevent acute kidney injury in patients undergoing orthognathic surgery, leading to better postoperative outcomes.
How similar studies have performed: While the approach of using controlled hypotension in surgery is established, the specific focus on early detection of AKI risk factors in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * America society anesthesiologist classification class I to II patients undergoing oro-maxillo-facial surgery * unlimited mouth opening Exclusion Criteria: * patients with arthritis with limited mouth opening * persistent liver dysfunction * chronic renal insufficiency * body mass index ≧35 kg/m2. * past history of malignant hyperthermia or personal or family history * diabetes with insulin treatment * essential hypertension without controlled
Where this trial is running
Kaohsiung City, Sanmin Dist
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Sanmin Dist, Taiwan (Recruiting)
Study contacts
- Principal investigator: Kuang-I Cheng, Phd — Kaohsiung Medical University Chung-Ho Memorial Hospital
- Study coordinator: Kuang-I Cheng, Phd
- Email: kuaich@gmail.com
- Phone: 886-7-3121101
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.