Analyzing immune responses to different COVID-19 vaccines using advanced techniques
Official title: Comparative Genetic and Immune Response Analysis of Different COVID-19 Vaccine Candidates Using Multi-OMICS Approach
Run by University Hospital Tuebingen · NCT04873128 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how different COVID-19 vaccines affect people's immune responses and side effects to help improve future vaccines.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | University Hospital Tuebingen Academic / other |
| Locations | 1 site (Tübingen) |
| Trial ID | NCT04873128 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include healthy individuals over 18 who have either recovered from COVID-19 or have not been infected, as well as vaccinated individuals experiencing complications post-vaccination.
✕Probably not a fit
Patients who are under 18 or those who cannot provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the varying immune responses and side effects experienced by individuals receiving different COVID-19 vaccines. By employing a Multi-OMICS approach, researchers will analyze blood samples to gather data from multiple biological levels, aiming to understand the genetic factors influencing these responses. The study seeks to clarify the unpredictable nature of vaccine reactions and explore long-term protection against SARS-CoV-2. Ultimately, the findings could inform the development of better vaccines and therapeutic strategies.
Why it matters
Potential benefit: If successful, this study could lead to improved COVID-19 vaccines and personalized vaccination strategies based on genetic predispositions.
How similar studies have gone: Other studies utilizing Multi-OMICS approaches have shown promise in understanding immune responses, suggesting potential for success in this novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Group 1 * Healthy donors (HD) who had recovered from COVID-19 disease and/or HD who did not have COVID-19 disease in the past * and who will receive the COVID-19 vaccine or a COVID19 vaccine candidate or other protective vaccines * HD who did receive one dose of a specific COVID19 vaccine but who will receive a different vac-cine for her/his second vaccination for completion of the immunization * Age \> 18 years Group 2 * Vaccinated subjects who are diagnosed with central thrombosis, anaphylactic shock or other major or minor complications such as atopic dermatitis (for example) after vaccination. * Age \> 18 years Exclusion Criteria: Group 1 and 2 - Missing informed consent of the subject
Where it's running
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University Hospital Tübingen
Tübingen, Germany Recruiting
Study contacts
- Study coordinator: Olaf Rieß, Prof. Dr.
- Email: olaf.riess@med.uni-tuebingen.de
- Phone: +49 7071 29
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.