Analyzing genetic mutations in appendiceal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients aged 18 and older diagnosed with appendiceal cancer that has spread to the peritoneum. It involves a retrospective analysis of archived tumor tissue from patients who have undergone cytoreductive surgery. The study aims to identify the proportion of genetic mutations in appendiceal cancers and compare these mutations between primary tumors and metastatic sites. By correlating genetic findings with clinical outcomes, the research seeks to enhance understanding of treatment responses and survival predictors in appendiceal cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Participants are eligible to be included in the study only if all of the following criteria apply:

1. Patients ≥ 18 years old who have been diagnosed with appendiceal cancer with peritoneal metastases,
2. have had cytoreductive surgery
3. have availability of archival tumour tissue

Exclusion Criteria:

* None

Where it's running

• The Christie NHS Foundation Trust
  Manchester, United Kingdom Recruiting

Study contacts

• Study coordinator: Richa Garvia
• Email: removed_due_to_spam@email.com
• Phone: 01614463000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Molecular profiling to improve risk stratification in appendiceal cancer

  Researchers test DNA methylation and m6A epitranscriptomic features in archived appendiceal cancer tissue to see if molecular subtypes and risk scores can better predict outcomes.

  Recruiting City of Hope Medical Center · Durate, California · NCT07587268

• Mass-based drug screening to guide personalized HIPEC for high-grade appendiceal and colorectal cancer with peritoneal spread.

  This tests whether a lab-based mass response test on tumor biopsies can pick the best chemotherapy to use during repeated HIPEC for people with unresectable peritoneal metastases from high-grade appendiceal or colorectal cancer.

  Recruiting Yale University · New Haven, Connecticut · NCT07291180

• Intraoperative imaging of gastrointestinal cancers using pafolacianine (CYTALUX™)

  This trial will test whether an injection of CYTALUX™ (pafolacianine) with near-infrared imaging helps surgeons find gastric, esophageal, or appendiceal adenocarcinomas during surgery in adults.

  Recruiting Phase 4 Cedars-Sinai Medical Center · Los Angeles, California · NCT07124351

• Combining local therapy with ongoing systemic treatment for certain cancers

  This study is testing whether adding local treatments to ongoing systemic therapy can help people with certain cancers keep their disease under control for longer.

  Recruiting University of California, Davis · Sacramento, California · NCT06101277

• Investigating the genetics of appendix cancer

  This study is trying to find out how genetics might play a role in appendix cancer by following adults with the disease for up to six years.

  Recruiting Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05734430

• Personalized chemotherapy for abdominal cancer treatment

  This study is testing a new way to personalize chemotherapy for patients with abdominal cancer by trying different treatments on their tumor samples before using them during surgery.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04847063

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.