Alveolar Ridge Preservation After Tooth Extraction Using Allograft Plus PRF or Barrier Membrane
Official title: Alveolar Ridge Preservation Using Bone Allografts With a PRF Membrane Versus GBR: A Randomized Controlled Clinical Trial
Run by Aristotle University Of Thessaloniki · NCT07818447 · Data updated 2026-11-12
This randomized study tests whether using bone allograft with a PRF membrane or with a resorbable barrier membrane better preserves the jawbone after tooth extraction, compared with spontaneous healing.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 51 (estimated) |
| Sponsor | Aristotle University Of Thessaloniki Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Thessaloniki, Thessaloniki) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | May 2027 |
| Study ends | May 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07818447 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) requiring extraction of a single tooth with surrounding periodontal involvement and good general health (ASA I–II) who will comply with follow-up.
✕Probably not a fit
Patients with conditions or habits severely impairing healing (e.g., uncontrolled systemic disease, heavy smoking) may not benefit or may experience less predictable outcomes.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults needing a single tooth extraction due to periodontal disease are randomized to receive one of three ridge-preservation approaches: bone allograft with a platelet-rich fibrin membrane, bone allograft with a barrier membrane, or natural healing without augmentation. The trial uses a parallel design with single-blind outcome assessment to compare dimensional changes in the extraction site, soft tissue parameters, and healing over time. Standardized surgical and measurement protocols ensure consistent data collection across participants. Primary aim is to determine which technique most effectively preserve alveolar bone and soft tissue contours for future implant placement.
Why it matters
Potential benefit: If successful, the approach could improve post-extraction bone preservation and esthetic outcomes for implants.
How similar studies have gone: Previous studies suggest guided bone regeneration approaches can improve healing; this trial builds on those findings with a direct comparison of two augmentation strategies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years. * Requirement for extraction of a single tooth affected by periodontal disease. * Presence of at least one adjacent tooth. * Loss of the buccal alveolar bone wall involving up to 50% of the socket wall. * Good general systemic health (American Society of Anesthesiologists ASA Physical Status I or II). * Satisfactory oral hygiene. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Systemic diseases or medications known to affect bone or soft tissue healing (e.g., uncontrolled diabetes mellitus, osteoporosis treated with bisphosphonates, or immunosuppressive therapy). * Heavy smoking (\>10 cigarettes/day). * Pregnancy or breastfeeding. * Presence of an acute infection or abscess at the extraction site. * History of radiotherapy to the head and neck region. * Inability or unwillingness to comply with the study protocol or attend scheduled follow-up visits.
Where it's running
-
Aristotle University of Thessaloniki, School of Dentistry, Faculty of Health Sciences, Postgraduate Periodontology Department
Thessaloniki, Thessaloniki, Greece Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.