Alternative treatment for placenta accreta
Official title: Conservative Management as an Alternative to Hysterectomy for Placenta Accreta Spectrum: a Pilot Randomized Controlled Trial.
Run by University of Utah · NCT05139498 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing a new way to manage placenta accreta that avoids surgery to see if it can be a safe and effective option for patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | Women only |
| Enrollment | 32 (estimated) |
| Sponsor | University of Utah Academic / other |
| Locations | 1 site (Salt Lake City, Utah) |
| Trial ID | NCT05139498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 and older with a history of cesarean delivery and suspected placenta accreta, who are typically recommended for hysterectomy.
✕Probably not a fit
Patients planning to deliver before 24 weeks gestation or those with low suspicion for PAS based on imaging may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot study evaluates the feasibility of conservative in situ management as an alternative to hysterectomy for patients with placenta accreta spectrum (PAS). The study aims to gather data on patient enrollment and adherence to treatment allocation, while monitoring safety and efficacy outcomes related to hemorrhage, transfusion, infection, and re-operation. By comparing these two treatment approaches, the study seeks to inform future randomized clinical trials and improve shared decision-making for patients facing this serious pregnancy condition.
Why it matters
Potential benefit: If successful, this approach could provide a safer and less invasive treatment option for patients with placenta accreta spectrum.
How similar studies have gone: While pilot studies like this one are limited, the concept of conservative management for PAS has shown promise in other contexts, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 and older * History of cesarean delivery AND placenta previa OR anterior low-lying placenta AND suspected of having PAS on prenatal imaging (ultrasound/MRI) * Patients who would typically be recommended for hysterectomy * Planned delivery between 34w0d and 36w0d gestation. Exclusion Criteria: * Plan to delivery before neonatal viability (\<24 weeks gestation) * Hospitalized for antenatal hemorrhage * Have a low antenatal suspicion for PAS based on imaging * Are pregnant with multiples (twins, triplets) * Have a uterine fetal demise
Where it's running
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University of Utah
Salt Lake City, Utah, United States Recruiting
Study contacts
- Principal investigator: Brett Einerson, MD — University of Utah
- Study coordinator: Ashley Joseph
- Email: ashley.joseph@hsc.utah.edu
- Phone: 801-903-3278
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.