Rehabilitation program to help people with methamphetamine-related heart and lung conditions
Official title: Feasibility of a Remote Collaborative Care-Facilitated Contingency Management-Exercise Rehabilitation Program for People With Methamphetamine-Associated Cardiopulmonary Conditions
Run by University of Utah · NCT07915882 · Data updated 2026-11-12
This study tests whether a 12-week, remotely delivered rehabilitation program with smartphone-based incentives can help people with methamphetamine-related heart failure or pulmonary arterial hypertension better control their stimulant use and improve health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Utah Academic / other |
| Locations | 1 site (Salt Lake City, Utah) |
| Status | Recruiting |
| Started | October 13, 2026 |
| Main results expected | October 31, 2028 |
| Study ends | October 31, 2028 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT07915882 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with methamphetamine-associated heart failure or methamphetamine-associated pulmonary arterial hypertension who actively use methamphetamine and have a smartphone, able to participate in virtual rehab.
✕Probably not a fit
Patients without active methamphetamine use or with conditions not meeting the inclusion criteria may derive limited benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study examines the feasibility and preliminary effectiveness of INSPIRE, a 12-week, remotely delivered collaborative care program for rural patients with methamphetamine-associated heart failure or pulmonary arterial hypertension. The intervention uses smartphone-based contingency management to incentivize participation in remote rehabilitation and exercise, alongside usual care. Eligible participants must have active methamphetamine use, a documented chronic heart condition, a smartphone, and the ability to engage in virtual rehabilitation; key exclusions include unstable cardiac conditions and language barriers. The study is led by Michael Incze with collaborators from NIDA and the University of Utah, and is based at University of Utah Health. Outcomes will focus on feasibility and early signals of impact on stimulant use and physical health.
Why it matters
Potential benefit: If successful, participants might see better control of stimulant use and improvements in heart and lung health related to methamphetamine exposure.
How similar studies have gone: Prior trials in stimulant-use disorders have shown promise for contingency management and remote rehabilitation approaches, though this specific combination for Me-HF/Me-PAH is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Active methamphetamine use determined by positive urine drug testing within the past 3 months and/or self-reported current use * Current diagnosis of chronic heart failure or pulmonary hypertension documented in the electronic health record * Possession of a smartphone * Able to participate in virtual exercise rehabilitation Exclusion Criteria: * Currently incarcerated * Unable to interact with smartphone app and/or virtual health coaching sessions in English * Unstable arrhythmia, defined as any known arrhythmia that is associated with hemodynamic effects like syncope, hypotension, or decompensated heart failure * Decompensated chronic heart failure or pulmonary hypertension * NYHA class IV symptoms * Myocardial infarction within the past 3 months, percutaneous coronary intervention within the past 2 weeks, coronary artery bypass graft within the past 3 months, or implantable cardiac defibrillator/cardiac resynchronization therapy/pacemaker implantation within the last 6 weeks * Unstable angina, uncontrolled hypertension, acute myocarditis/pericarditis, intracardiac thrombus * Severe symptomatic aortic stenosis
Where it's running
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University of Utah Health
Salt Lake City, Utah, United States Recruiting
Study contacts
- Principal investigator: Michael A Incze, MD — University of Utah
- Study coordinator: Michael A Incze, MD
- Email: Michael.Incze@hsc.utah.edu
- Phone: 801-581-2000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.