AI tool for personalized sepsis treatment recommendations
Passive Evaluation in Operational Environment of the AI Clinician Decision Support System for Sepsis Treatment
This study is testing an AI tool that helps doctors give the right medication doses for sepsis treatment in ICU patients to see if it can improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Imperial College London Academic / other |
| Locations | 2 sites (London and 1 other locations) |
| Trial ID | NCT05287477 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates an artificial intelligence clinician decision support system designed to personalize medication dosing for sepsis treatment in ICU patients. The AI tool continuously analyzes patient data from electronic health records to recommend optimal intravenous fluids and vasopressor doses, addressing the significant variability in sepsis treatment. By leveraging reinforcement learning techniques, the system aims to improve patient outcomes and reduce the economic burden of sepsis care. The study will refine the tool based on real-world operational feedback from ICU doctors.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old who are admitted to an ICU with a likely or confirmed diagnosis of sepsis and have an expected ICU stay of more than 24 hours.
Not a fit: Patients who are not for full active care, expected to survive less than 24 hours, or those admitted for elective surgery will not benefit from this study.
Why it matters
Potential benefit: If successful, this AI tool could significantly improve survival rates for sepsis patients by providing tailored treatment recommendations.
How similar studies have performed: Previous studies have shown promise in using AI for clinical decision support in sepsis treatment, indicating potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For patients: * Adult patient \> 18 years old * Admitted to an intensive care unit * Likely or confirmed diagnosis of sepsis as per sepsis-3 definition (as defined in the glossary) * ICU length of stay \> 24h For Evaluators: - ICU doctors at the senior registrar, ICU fellow or consultant level Exclusion Criteria: For patients: * Not for full active care, e.g. not for vasopressors * Not expected to survive more than 24h * Elective surgical admission (these patients are regularly on antibiotics but given as a prophylaxis, with no sepsis) * Opted-out for use of their data for research (NHS and NHS-X website) For both patients and evaluators: Declined participation No patient consent is required
Where this trial is running
London and 1 other locations
- Univeristy College London Hospitals NHS Foundation Trust — London, United Kingdom (Not_yet_recruiting)
- Imperial College Hospitals NHS Trust — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Anthony C Gordon
- Email: anthony.gordon@imperial.ac.uk
- Phone: 02033126328
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.