AI tool for personalized sepsis treatment recommendations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates an artificial intelligence clinician decision support system designed to personalize medication dosing for sepsis treatment in ICU patients. The AI tool continuously analyzes patient data from electronic health records to recommend optimal intravenous fluids and vasopressor doses, addressing the significant variability in sepsis treatment. By leveraging reinforcement learning techniques, the system aims to improve patient outcomes and reduce the economic burden of sepsis care. The study will refine the tool based on real-world operational feedback from ICU doctors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For patients:

* Adult patient \> 18 years old
* Admitted to an intensive care unit
* Likely or confirmed diagnosis of sepsis as per sepsis-3 definition (as defined in the glossary)
* ICU length of stay \> 24h

For Evaluators:

- ICU doctors at the senior registrar, ICU fellow or consultant level

Exclusion Criteria:

For patients:

* Not for full active care, e.g. not for vasopressors
* Not expected to survive more than 24h
* Elective surgical admission (these patients are regularly on antibiotics but given as a prophylaxis, with no sepsis)
* Opted-out for use of their data for research (NHS and NHS-X website)

For both patients and evaluators:

Declined participation No patient consent is required

Where it's running

• Imperial College Hospitals NHS Trust
  London, United Kingdom Recruiting
• Univeristy College London Hospitals NHS Foundation Trust
  London, United Kingdom Not yet recruiting

Study contacts

• Study coordinator: Anthony C Gordon
• Email: anthony.gordon@imperial.ac.uk
• Phone: 02033126328

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care

  This trial tests whether adding Ruta C (rutin plus vitamin C) or vitamin C alone to standard sepsis treatment helps adults in the ICU stay shorter and recover better.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07922213

• Early detection of sepsis-related blood clotting problems in severe burn patients

  This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.

  Recruiting Center for Traumatology and Major Burns, Ben Arous · Tunis · NCT07914205

• Neutrophil EMR3 as a biomarker for sepsis in ICU patients

  Researchers will test whether measuring EMR3 on neutrophils helps diagnose sepsis, monitor progression, and predict outcomes in adults in Chinese ICUs.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07896018

• Thymalfasin added to standard care for adults with sepsis and immune dysfunction

  This study tests whether thymosin alpha-1 helps restore immune function in adults with sepsis who have weakened immunity.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07866118

• Multicenter group study of sepsis and ARDS in China

  This study tests how sepsis and ARDS differ among adults across several Chinese hospitals and builds a biobank to understand why some patients do better or worse.

  Recruiting at 24 sites Shanghai Zhongshan Hospital · Xiamen, Fujian and 23 other locations · NCT07863908

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.