AI-guided blood-pressure and fluid management during cytoreductive surgery with HIPEC

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a pilot interventional comparison of an AI-derived hemodynamic protocol (HPI-AFM) versus standard goal-directed therapy during cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). The protocol uses predictive and flow-derived parameters to guide vasopressor and fluid decisions with the aim of reducing intraoperative hypotension and optimizing stroke volume. Outcomes include amount and duration of intraoperative hypotension, fluid volumes given, and early postoperative complications such as acute kidney injury and pulmonary effusion. The trial is single-center and enrolls adults scheduled for CRS-HIPEC for ovarian cancer, excluding patients with arrhythmias or pregnancy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age \> 18 years
* patient scheduled for CRS for ovarian cancer

Exclusion Criteria:

* patients' refusal
* cardiac arrythmia
* pregnancy.

Where it's running

• IRCCS Fondazione Policlinico A. Gemelli
  Rome, Italy Recruiting

Study contacts

• Principal investigator: Luciano Frassanito — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Luciano Frassanito, MD
• Email: luciano.frassanito@policlinicogemelli.it
• Phone: +393475256158

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.