AI-assisted MDS-UPDRS assessment in Parkinson’s disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective observational study conducted at Queen Elizabeth Hospital in Hong Kong to develop and validate an AI-based MDS-UPDRS Part III scoring system using synchronized RGB video data. Participants will receive standard MDS-UPDRS III assessments by a clinician or physiotherapist while being video-recorded, and the AI system will generate scores from the video. Blinded comparisons will evaluate agreement between AI-derived scores and ground-truth clinician ratings, with analyses including inter-rater reliability, sensitivity to change, and subgroup analyses. The study aims to determine if video-based AI scoring can reliably reflect motor severity in idiopathic Parkinson’s disease. Eligibility requires adults with clinically established PD who consent to video-recorded assessments and have no impairments interfering with video-based evaluation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years
2. Diagnosis of "Clinically Established PD" as defined by the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (MDS-PD criteria) \[12\]
3. Able to provide informed consent and willing to participate in video-recorded MDS-UPDRS Part III assessments
4. No significant visual, auditory, or musculoskeletal impairments that would interfere with video-based motor assessments

Exclusion Criteria:

1. Unwillingness to be video recorded for study purposes
2. History of neurodevelopmental disorder, neurodegenerative disease other than PD, CNS infection, neuroinflammatory disease (e.g. multiple sclerosis, CNS lupus), malignancy within the last 10 years, cerebrovascular accident, HIV infection, systemic autoimmune disease, alcohol dependence or other substance use

Where it's running

• Queen Elizabeth Hospital
  Hong Kong, Hong Kong Recruiting
• Hong Kong University of Science and Technology
  Hong Kong, China Not yet recruiting

Study contacts

• Principal investigator: Qian Zhang, PhD — Hong Kong University of Science and Technology
• Study coordinator: Qian Zhang, PhD
• Email: qianzh@ust.hk
• Phone: +852-23588766

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.