Aerobic exercise's effect on immune response in cancer patients
Acute Effect of Moderate and High-Intensity Aerobic Exercise on the Anticancer Immune Response in Individuals Undergoing Treatment for Curable Cancer
NA · Université de Sherbrooke · NCT06911970
This study tests if aerobic exercise can help boost the immune response in patients with non-metastatic breast or colorectal cancer during their treatment.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Ages | 40 Years to 70 Years |
| Sex | All |
| Sponsor | Université de Sherbrooke (other) |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 2 sites (Sherbrooke, Quebec and 1 other locations) |
| Trial ID | NCT06911970 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how aerobic exercise influences the mobilization and functionality of anticancer immune cells in patients undergoing treatment for non-metastatic breast or colorectal cancer. The study aims to determine whether exercise can enhance the migratory capacity of immune cells, such as natural killer cells and cytotoxic T lymphocytes, and whether the intensity of exercise affects this response. By examining the relationship between exercise and immune activation, the trial seeks to explore the potential of exercise as an adjunct to cancer immunotherapy.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 40 to 70 with non-metastatic breast or colon cancer who are currently undergoing chemotherapy or immunotherapy.
Not a fit: Patients with orthopedic, cardiac, or metabolic limitations that prevent safe aerobic exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of cancer treatments by utilizing exercise to boost the immune response against tumors.
How similar studies have performed: Previous studies have shown promising results regarding the role of exercise in enhancing anticancer immunity, suggesting that this approach may be viable.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of non-metastatic breast or colon cancer * Age between 40 and 70 * Have started chemotherapy or immunotherapy treatment and have at least three treatments remaining in the cycle * ECOG stage 0 to 1 * Be able to perform moderate-intensity aerobic exercise (MOD) or EPI type cycling according to the established prescription and without experiencing pain in connection with the bicycle saddle Exclusion Criteria: * Orthopedic, cardiac or metabolic limitation preventing safe aerobic exercise * Non-controlled health condition * Use of beta-blockers * Planned surgery during the study period.
Where this trial is running
Sherbrooke, Quebec and 1 other locations
- Research Center on Aging — Sherbrooke, Quebec, Canada (RECRUITING)
- Research Center on Aging — Sherbrooke, Quebec, Canada (NOT_YET_RECRUITING)
Study contacts
- Principal investigator: Eléonor Riesco, PhD — University of Sherbrooke, Faculty of Physical Activity Sciences, Department of Kinanthropology
- Study coordinator: Eléonor Riesco, PhD
- Email: eleonor.riesco@usherbrooke.ca
- Phone: 819-821-8000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Colorectal Cancer, Breast Cancer, Non Metastatic Cancer, cancer, exercise, T cells, NK cells, Migration