Advanced PRF with Hyaluronic Acid at Implant Sites to Improve Healing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group study compares the use of advanced platelet-rich fibrin (A-PRF) plus hyaluronic acid (HA) versus standard implant placement without these adjuncts in adults needing a delayed dental implant in the posterior mandible. Peri-implant bone formation and density are measured by CBCT, along with implant stability using resonance frequency analysis, at placement and during six months of follow-up. Additional outcomes include postoperative pain and implant survival. The trial will follow participants for six months to assess early healing and osseointegration with the adjunctive biomaterials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Adults aged 18-65 years.

Patients requiring delayed dental implant placement in a posterior mandibular edentulous site

Sufficient residual alveolar bone height and width to permit conventional implant placement without the need for simultaneous guided bone regeneration (GBR), ridge augmentation, or other bone-grafting procedures.

Good general health or a medically controlled and stable systemic condition compatible with elective implant surgery and not expected to materially compromise wound or bone healing.

Non-smokers with no current use of tobacco products.

Acceptable oral hygiene and a periodontal condition compatible with implant surgery following any required professional treatment and reassessment.

Ability and willingness to undergo the required clinical and radiographic assessments, including CBCT examinations at baseline and at the 6-month follow-up.

Ability and willingness to attend the scheduled follow-up visits and comply with the study procedures.

Provision of written informed consent before study participation.

Exclusion Criteria:

\-

Any uncontrolled systemic disease or medical condition that conensions for conventional implant placement without augmentation.

Requirement for immediate implant placement, simultaneous guided bone regeneration, ridge augmentation, or any other adjunctive bone-grafting procedure.

Inability or unwillingness to complete the required 6-month clinical and radiographic follow-up.traindicates elective implant surgery or may substantially impair wound or bone healing, including uncontrolled diabetes mellitus.

Immunocompromised status or current systemic immunosuppressive therapy.

Current or previous use of oral or parenteral bisphosphonates or other antiresorptive medications associated with a risk of medication-related osteonecrosis of the jaw.

Pregnancy at the time of screening or enrollment.

Unresolved active periodontal disease or active local infection involving the intended implant site, including suppuration.

Inadequate oral hygiene that persists after professional oral-hygiene instruction, necessary periodontal treatment, and reassessment.

Insufficient residual alveolar bone dim

Where it's running

• Beauty Smile Dental Center
  Sanaa, Sana'a, Yemen Recruiting

Study contacts

• Principal investigator: Samar A salamah, BDS — Sana'a University
• Study coordinator: Samar A Salamah, BDS
• Email: samarali777277949@gmail.com
• Phone: +967777277949

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.