Adequacy of Middle Molecules Clearance in Haemodiafiltration and its Relation to Patient Outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares high (>23 L) versus low (<23 L) convection volumes in haemodiafiltration and examines how dialysate sodium concentration (137 vs 140 mmol/L) influences overhydration in patients receiving hemodialysis or haemofiltration. The goal is to see if better removal of middle molecules correlates with improved patient-reported symptoms and nutritional status, beyond traditional small-molecule metrics like Kt/V. The analysis will consider quality of life, hydration status, and nutrition, acknowledging that dialysis effectiveness today includes multiple factors beyond urea clearance. Participants include adults with end-stage kidney disease on dialysis for at least 3 months and a projected prognosis over 6 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or above.
* Ability to give informed consent.
* End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months.
* Prognosis \> 6 months as assessed by principal investigator (PI)

Where it's running

• Lister Hospital, East and North Hertfordshire NHS Trust
  Stevenage, Hertfordshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Usama Afzal Butt, MBBS, MRCP — East and North Hertfordshire NHS Trust
• Study coordinator: Usama Afzal Butt, MBBS, MRCP (UK)
• Email: usama.butt1@nhs.net
• Phone: +441438284340

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.