Adding zinc to Botox for cervical dystonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind, placebo-controlled crossover trial will enroll about 20 adults with cervical dystonia who already receive regular botulinum toxin type A injections at the University of Florida Movement Disorders Clinic. Participants will take zinc citrate 30 mg daily or matching placebo for three months after a scheduled Botox injection, then switch to the other treatment for another three months while keeping the same injection pattern. Outcomes include duration of symptom relief after injections, safety and tolerability measured by serum zinc, vitamin B12 and CBC, and patient-reported quality of life and functional measures. Clinic visits and blood draws occur every three months to coincide with routine Botox injections.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-89 years.
* Diagnosed with cervical dystonia.
* Receiving regular BoNT type A (Botox) injections for at least six months.

Exclusion Criteria:

* Known allergy or intolerance to zinc.
* Significant comorbidities or concurrent medications that could interfere with study outcomes.
* Pregnant or breastfeeding women.
* Already taking a zinc supplement which would exceed tolerable upper intake level in adults (40 mg elemental zinc per day) with addition of zinc study supplement.

Where it's running

• Norman Fixel Institute for Neurological Diseases
  Gainesville, Florida, United States Recruiting

Study contacts

• Principal investigator: Lauren Fanty, MD — University of Florida
• Study coordinator: Julie Segura, BA
• Email: Julie.Segura@neurology.ufl.edu
• Phone: 352-733-2412

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Targeted Focused Ultrasound for Cervical Dystonia

  This trial tests whether applying theta burst focused ultrasound to brain regions GPi or DN, or a sham, can help people with cervical dystonia.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07690514

• Noninvasive brain stimulation for cervical dystonia using continuous theta-burst in a sham-controlled trial

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• Vibration to improve head posture in cervical dystonia

  This trial will test whether stronger vibration applied to the neck muscles helps correct abnormal head posture in people with cervical dystonia.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07245615

• IPN10200 treatment for cervical dystonia in adults

  This trial will test whether a single injection of IPN10200 (one of two doses) reduces neck posture problems, pain, and disability better than placebo in adults with cervical dystonia.

  Recruiting at 27 sites Phase 2 Ipsen · Tucson, Arizona and 44 other locations · NCT06937931

• Using Valbenazine with Botulinum Toxin for Cervical Dystonia

  This study is testing if adding a medication called valbenazine to botulinum toxin injections can help people with cervical dystonia feel better and improve their quality of life.

  Recruiting Phase 2 Virginia Commonwealth University · Richmond, Virginia · NCT06771323

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.