Adding anti-inflammatory treatment for acute aortic conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

A multicenter observational registry across Chinese cardiovascular centers is enrolling consecutive adults who underwent surgery for acute aortic syndrome from January 1, 2016 through December 31, 2040. The project collects clinical data, procedural details, inflammatory markers, and information on medical, open, endovascular, or hybrid treatments. Primary early outcomes include severe SIRS, multiple organ dysfunction syndrome (MODS), and SOFA scores at 7 days, with additional long-term adverse event tracking. By comparing inflammatory responses and anti-inflammatory strategies across patients, the registry aims to clarify how inflammation influences short- and long-term outcomes after AAS surgery.

Why it matters

Who can join: the full rules

Inclusion criteria

* Aged 18 years or older.
* Patients with diagnosis of AAS, including aortic dissection, penetrating aortic ulcer or intramural hematoma.
* Symptoms started within 14 days from surgery.
* Patients received medical therapy, open surgical, endovascular, or hybrid repair.
* Any other major cardiac surgical procedure concomitant with surgery for AAS, such as coronary artery bypass grafting or carotid artery replacement;
* The patient or guardian agrees to participate in this study. Exclusion criteria
* Patients aged \< 18 years.
* Onset of symptoms \> 14 days from surgery.
* AAS secondary to traumatic or iatrogenic injury.
* Patients who declined participation in registration and follow-up investigation.

Where it's running

• Beijing Fuwai Hospital Chinese Academy of Medical Sciences
  Beijing, Beijing Municipality, China Recruiting
• Chongqing Hospital of Jiangsu Provincial People's Hospital
  Chongqing, Chongqing Municipality, China Recruiting
• Guangdong Provincial People's Hospital
  Guangzhou, Guangdong, China Recruiting
• The First Affiliated Hospital of Guangxi Medical University
  Nanning, Guangxi, China Recruiting
• QianXiNan People's Hospital
  Xingyi, Guizhou, China Recruiting
• The Second Affiliated Hospital of Harbin Medical University
  Harbin, Heilongjiang, China Recruiting

Study contacts

• Principal investigator: Hong Liu — Nanjing Medical University
• Study coordinator: Hong Liu, MD
• Email: DR.HONGLIU@FOXMAIL.COM
• Phone: 02568303100

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating a new stent graft for treating acute aortic syndrome

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  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT05965453

• Using statins to protect heart health after aortic surgery

  This study tests if the cholesterol-lowering drug rosuvastatin can help people recover better and protect their heart health after surgery for serious aortic problems.

  Recruiting at 5 sites Nanjing Medical University · Guangzhou, Guangdong and 4 other locations · NCT04699279

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.