Using statins to protect heart health after aortic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the protective effects of the statin rosuvastatin in patients who have undergone surgery for acute aortic syndrome, such as aortic dissection or aneurysm. The study focuses on individuals without significant hyperlipidemia but with cardiovascular risk factors, hypothesizing that statins can reduce inflammation and improve cardiovascular outcomes. Participants will receive a daily dose of 10mg rosuvastatin and will be monitored for improvements in cardiovascular health post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* (1) Patients with aortic dissection/ulceration/intermural hematoma/aortic aneurysm who underwent aortic arch replacement or endoluminal isolation or hybrid therapy;
* (2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors (such as male ≥45 years old, female ≥55 years old, hypertension, diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol consumption, family history of early onset ischemic cardiovascular disease) and no previous use of statins;
* (3) Patients are between 18 and 85 years old, male or female;
* (4) Agree to participate in the study and sign the informed consent.

Exclusion Criteria:

* (1) Patients with allergy to statins;
* (2) patients with active liver disease;
* (3) patients with myopathy;
* (4) Lactating women and pregnant women;
* (5) Patients with mental diseases, drug and alcohol dependence;
* (6) Refuse to participate in the study or sign the informed consent.

Where it's running

• The First Affiliated Hospital of Guangzhou Medical University
  Guangzhou, Guangdong, China Recruiting
• The first affiliated hospital of nanjing medical university
  Nanjing, Jiangsu, China Recruiting
• Affiliated Hospital of Qingdao University
  Qingdao, Shandong, China Recruiting
• West China Hospital of Sichuan University
  Chengdu, Sichuan, China Recruiting
• Beijing Anzhen Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Hong Liu, MD
• Email: DR.HONGLIU@FOXMAIL.COM
• Phone: 18801281613

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using ADD-RS and D-dimer to rule out acute aortic syndrome in the ED

  In the emergency department, doctors test whether ADD-RS and a D-dimer result can safely rule out acute aortic syndrome in adults suspected of AAS.

  Recruiting Chinese University of Hong Kong · Hong Kong and 1 other locations · NCT07640334

• Evaluating a new stent graft for treating acute aortic syndrome

  This study is testing a new type of stent graft to see if it is safe and effective for people with acute aortic syndrome who don't have enough support for traditional treatment.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT05965453

• Adding anti-inflammatory treatment for acute aortic conditions

  This registry will follow adults having surgery for acute aortic syndrome to see if inflammation and anti-inflammatory approaches affect recovery and complications.

  Recruiting at 30 sites Nanjing Medical University · Beijing, Beijing Municipality and 33 other locations · NCT04398992

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.