Acute Response to Blood Flow Restriction Training With Dynamic vs Fixed Pressure in Severe Knee Osteoarthritis
Official title: Acute Responses to Different Blood Flow Restriction Exercise Configurations With Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis
Run by University of Valencia · NCT07316933 · Data updated 2026-11-12
This study tests whether dynamic pressure BFR training differs from fixed pressure BFR training in producing short-term pain relief and neuromuscular responses for people awaiting knee replacement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 85 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Valencia Academic / other |
| Locations | 1 site (Valencia, Valencia) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT07316933 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Candidates are adults 50–85 with severe knee OA awaiting unilateral knee replacement.
✕Probably not a fit
Patients who do not experience pain relief or adverse responses to BFR or who have contraindications to exercise may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 50–85 with severe knee osteoarthritis who are on a waiting list for unilateral knee replacement will undergo six randomized sessions comparing different combinations of exercise intensity and blood flow restriction pressure. Each session uses low to moderate resistance with varying occlusion levels and pressure configurations (dynamic versus fixed), separated by at least 72 hours. Outcomes focus on acute changes in pain perception and neuromuscular responses to the exercise. The design contrasts six training conditions to determine if pressure mode and occlusion level influence immediate benefits. The study is conducted at the University of Valencia with six sessions per participant.
Why it matters
Potential benefit: If successful, dynamic pressure BFR could offer greater pain relief and favorable neuromuscular responses during rehab for knee OA.
How similar studies have gone: Previous research in BFR training has shown positive acute effects in diverse populations, but results vary by pressure configuration and participant condition.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 50 and 85 years * Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines. * On the waiting list for unilateral total knee replacement (TKR) surgery Exclusion Criteria: * Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog scale (VAS) during daily activities. * Previous hip or knee replacement surgery and osteotomy within the last year. * Autoimmune arthritis * Medical conditions that contraindicate exercise. * Participation in exercise programs (\>2 days/week with training at intensities of 10-15 1RM) in the previous six months. * History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study. * Cardiovascular, thrombotic, or vascular risk factors (uncontrolled hypertension, peripheral arterial disease, history of deep vein thrombosis or pulmonary embolism, heart failure, severe varicose veins, or uncontrolled anticoagulant therapy). * Skin or local alterations at the cuff application site (ulcers, open wounds, infections, lymphedema, or severe edema). * Inability to communicate normally or with impaired communication skills.
Where it's running
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University of Valencia
Valencia, Valencia, Spain Recruiting
Study contacts
- Study coordinator: Adrián Escriche-Escuder, PhD
- Email: adrian.escriche@uv.es
- Phone: +34 963 98 38 55
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.