Acute Kidney Injury Risk During an Ultra-Endurance Run

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study follows a single-group, pre- and post-test design to assess kidney function in runners during the Western States Endurance Run. Researchers will collect urine and small blood samples, measure body weight, and record NSAID use before, immediately after, and 24 hours after the race. Participants will wear GPS and heart-rate devices to track exertion and gait metrics. The trial compares sodium bicarbonate to placebo to see if the supplement alters kidney injury markers collected with modern urinary biomarkers. No long-term follow-up is planned, and the study will enroll adult runners without preexisting kidney disease who meet safety criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Running in the Western States Endurance Run in either 2026, 2027 or 2028
* No contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire (PAR-Q+) as prepared by the American College of Sports Medicine (ACSM)
* Not currently taking medicine or experiencing illness that may influence the cardiovascular or neuromuscular system
* Age ≥18 and ≤ 50 years old and injury free (skeletal muscle) for \> 3 months

Exclusion Criteria:

* Minors (under 18)
* Adults who are unable to consent (impaired decision-making capacity)
* Prisoners
* Pregnant Women
* Individuals with known kidney disease, or are on any medication that specifically effects kidney function (e.g., diuretics)

Where it's running

• ASU Health Futures Center
  Phoenix, Arizona, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.