Vinegar for Heartburn relief tested in a small crossover study

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized crossover trial compares liquid vinegar to a vinegar tablet as a treatment for heartburn in adults who experience symptoms at least twice weekly and do not have erosive reflux disease. Participants identify trigger foods and consume two targeted foods during two visits after a 4-hour fast, once with liquid vinegar and once with a vinegar tablet, in randomized order. Symptoms are reported every 10-15 minutes for two hours after eating using a validated heartburn measure. The study focuses on symptom relief rather than mechanisms of reflux, and aims to enroll 22 participants at a single site in Phoenix, Arizona. Both safety and tolerability of vinegar forms will be monitored during the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* report heartburn symptoms two or more times a week for several weeks or months
* Any over the counter PPI use (proton-pump inhibitors such as Prilosec, Nexium, Prevacid) will need to be restricted for one month.

Exclusion Criteria:

* Drug use (prescription, over-the-counter, or otherwise) known to affect the stomach and digestive processes, including GLP-1 RA or GLP/GIP medications
* Medical conditions that impact normal functioning of the gastrointestinal tract (e.g., Crohn's disease, Celiac disease, short bowel syndrome, ostomy, lactose intolerance, hernia , SIBO, H. Pylori positive hasn't been cleared etc.).
* Excess alcohol use (\>2 servings daily)

Where it's running

• Arizona Biomedical Collaborative
  Phoenix, Arizona, United States Recruiting

Study contacts

• Study coordinator: Carol Johnston, PhD
• Email: carol.johnston@asu.edu
• Phone: 6024963463

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.