Investigating kidney blood flow changes after traumatic injury
Renal Perfusion and the Development of AKI Following Traumatic Injury - A Longitudinal Observational Cohort Study
This study looks at how blood flow to the kidneys changes in patients who have had serious injuries and are at risk for kidney problems after receiving blood products.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | King's College Hospital NHS Trust Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06917053 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore how traumatic hemorrhagic shock affects renal microcirculatory perfusion in patients who have experienced traumatic injuries. By utilizing advanced imaging techniques such as ultrasound and sublingual incident dark field videomicroscopy, the study will assess intra-renal perfusion changes in the early hours following ICU admission. The research focuses on patients who have received blood products and have elevated lactate levels, indicating a risk for acute kidney injury (AKI).
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have been admitted to the ICU within 24 hours of a traumatic injury and have received blood products.
Not a fit: Patients with known chronic kidney disease stage 4 or end-stage renal failure, as well as those with un-survivable injuries, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of acute kidney injury in trauma patients, potentially reducing mortality rates.
How similar studies have performed: While there is existing knowledge regarding AKI in septic shock patients, this specific investigation into renal perfusion changes following traumatic hemorrhagic shock is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Within 24 hours of ICU admission following traumatic injury * Received any blood products during initial resuscitation * Lactate \> 2 mmol/l at any stage prior to study enrolment Exclusion Criteria: * Known intolerance to Sonovue or any other ultrasound contrast agent * Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative * Known CKD 4 or end stage renal failure * Pregnancy
Where this trial is running
London
- King's College Hospital — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Sam Hutchings
- Email: sam.hutchings@nhs.net
- Phone: +442032994957
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.