Investigating kidney blood flow changes after traumatic injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore how traumatic hemorrhagic shock affects renal microcirculatory perfusion in patients who have experienced traumatic injuries. By utilizing advanced imaging techniques such as ultrasound and sublingual incident dark field videomicroscopy, the study will assess intra-renal perfusion changes in the early hours following ICU admission. The research focuses on patients who have received blood products and have elevated lactate levels, indicating a risk for acute kidney injury (AKI).

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years
* Within 24 hours of ICU admission following traumatic injury
* Received any blood products during initial resuscitation
* Lactate \> 2 mmol/l at any stage prior to study enrolment

Exclusion Criteria:

* Known intolerance to Sonovue or any other ultrasound contrast agent
* Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative
* Known CKD 4 or end stage renal failure
* Pregnancy

Where it's running

• King's College Hospital
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Sam Hutchings
• Email: sam.hutchings@nhs.net
• Phone: +442032994957

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.