Acute Effects of Different MCT Formulations on Ketone, Lipid, and Glucose Responses in Healthy Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized crossover trial compares five lipid formulations, including various MCTs and LCTs, delivered as beverages or foods, to see how they influence post-meal ketone (beta-hydroxybutyrate), triglyceride, and glucose responses. Participants receive each test product in random order after an overnight fast, with at least seven days between visits. Primary outcomes are postprandial beta-hydroxybutyrate, glucose, and triglyceride levels over five hours; secondary outcomes include fatty acid profiles. The study explores the effects of fatty-acid composition and food form (powder versus solid) on metabolic responses in healthy adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy adult participants
* Age between 18 and 40 years
* Ability to understand the study procedures and provide informed consent

Exclusion Criteria:

* Alterations in glucose or lipid metabolism
* Diseases requiring the use of medications that affect glucose or lipid metabolism
* Reported or diagnosed malabsorption conditions
* Pregnancy or breastfeeding

Where it's running

• International Center for the Assessment of Nutritional Status and the development of Dietary Intervention Strategies (ICANS-DIS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan
  Milan, Italy Recruiting

Study contacts

• Study coordinator: Alessandro Leone
• Email: alessandro.leone1@unimi.it
• Phone: 00390250316652

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.