Clinical trial Recruiting at 1 site Interventional Ages 18 to 60

Active oxygen gel vs hyaluronic acid gel for palatal healing after graft harvest

Official title: Effectiveness of Active Oxygen Gel Versus Hyaluronic Acid Gel on Palatal Wound Healing After Free Gingival Graft: A Randomized Controlled Clinical Trial

Run by Suez Canal University · NCT07683351 · Data updated 2026-11-12

This randomized trial tests whether active oxygen gel or hyaluronic acid gel, each used with a protective dressing, improve palatal wound healing after a free gingival graft compared with a standard gelatin sponge dressing.

More Mucogingival Defects trials

Quick facts

Study typeInterventional
Ages18 Years to 60 Years
SexAll
Enrollment30 (estimated)
SponsorSuez Canal University
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Ismailia, Ismailia Governorate)
StatusRecruiting
StartedAugust 27, 2025
Main results expectedAugust 27, 2026
Study endsAugust 30, 2026
Registry record updatedJuly 22, 2026
Trial IDNCT07683351 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18-60 with mucogingival defects requiring a free gingival graft and adequate palatal thickness (>3 mm).

Probably not a fit

Patients with poor oral hygiene, systemic conditions, smoking, pregnancy, immunocompromised status, or noncompliance may not experience benefits.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Thirty healthy adults with mucogingival defects needing a free gingival graft will be randomly assigned to three equal groups to receive different palatal dressings after graft harvesting. Group A uses a gelatin sponge with flowable composite, Group B uses hyaluronic acid gel with a gelatin sponge and flowable composite, and Group C uses active oxygen gel with a gelatin sponge and flowable composite. Outcomes include pain, analgesic use, wound healing quality, and complete re-epithelialization, assessed over the postoperative period. The study aims to determine which dressing material best supports donor-site recovery. Procedures follow standard graft harvesting techniques and postoperative care under ethical oversight at Suez Canal University.

Why it matters

Potential benefit: If successful, the best-performing dressing could reduce pain and improve healing at the donor site.

How similar studies have gone: Previous studies have explored different palatal dressings, with some showing improvements in healing, but direct comparisons among these specific gels are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Systemically healthy patients Age between 18 and 60 years Patients with mucogingival defects requiring free gingival graft Adequate palatal thickness (\>3 mm) Cooperative and motivated patients Good oral hygiene compliance

Exclusion Criteria:

Systemic diseases that contraindicate surgical procedures Smokers Pregnant or lactating females Immunocompromised patients Patients undergoing chemotherapy or radiotherapy Poor oral hygiene or non-compliant patients Palatal infection

Where it's running

  • Faculty of Dentistry, Suez Canal University
    Ismailia, Ismailia Governorate, Egypt
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.