Active oxygen gel vs hyaluronic acid gel for palatal healing after graft harvest
Official title: Effectiveness of Active Oxygen Gel Versus Hyaluronic Acid Gel on Palatal Wound Healing After Free Gingival Graft: A Randomized Controlled Clinical Trial
Run by Suez Canal University · NCT07683351 · Data updated 2026-11-12
This randomized trial tests whether active oxygen gel or hyaluronic acid gel, each used with a protective dressing, improve palatal wound healing after a free gingival graft compared with a standard gelatin sponge dressing.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Suez Canal University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Ismailia, Ismailia Governorate) |
| Status | Recruiting |
| Started | August 27, 2025 |
| Main results expected | August 27, 2026 |
| Study ends | August 30, 2026 |
| Registry record updated | July 22, 2026 |
| Trial ID | NCT07683351 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-60 with mucogingival defects requiring a free gingival graft and adequate palatal thickness (>3 mm).
✕Probably not a fit
Patients with poor oral hygiene, systemic conditions, smoking, pregnancy, immunocompromised status, or noncompliance may not experience benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Thirty healthy adults with mucogingival defects needing a free gingival graft will be randomly assigned to three equal groups to receive different palatal dressings after graft harvesting. Group A uses a gelatin sponge with flowable composite, Group B uses hyaluronic acid gel with a gelatin sponge and flowable composite, and Group C uses active oxygen gel with a gelatin sponge and flowable composite. Outcomes include pain, analgesic use, wound healing quality, and complete re-epithelialization, assessed over the postoperative period. The study aims to determine which dressing material best supports donor-site recovery. Procedures follow standard graft harvesting techniques and postoperative care under ethical oversight at Suez Canal University.
Why it matters
Potential benefit: If successful, the best-performing dressing could reduce pain and improve healing at the donor site.
How similar studies have gone: Previous studies have explored different palatal dressings, with some showing improvements in healing, but direct comparisons among these specific gels are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Systemically healthy patients Age between 18 and 60 years Patients with mucogingival defects requiring free gingival graft Adequate palatal thickness (\>3 mm) Cooperative and motivated patients Good oral hygiene compliance Exclusion Criteria: Systemic diseases that contraindicate surgical procedures Smokers Pregnant or lactating females Immunocompromised patients Patients undergoing chemotherapy or radiotherapy Poor oral hygiene or non-compliant patients Palatal infection
Where it's running
-
Faculty of Dentistry, Suez Canal University
Ismailia, Ismailia Governorate, Egypt Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.