Accelerating tooth movement with MOP, prostaglandin E1, and calcitriol

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 trial compares three interventions—micro-osteoperforation, prostaglandin E1 injections, and calcitriol injections—to see if they can accelerate the rate of orthodontic tooth movement in adults aged 18 to 25 receiving fixed appliances for non-extractive treatment. Participants are healthy in terms of periodontal status and must have a specific crowding range in the lower front teeth. The study uses local administration of the agents or surgical stimulation as adjuncts to standard orthodontic care, with safety and movement rate as key outcomes. The trial is conducted at two units within the College of Dentistry, University of Baghdad, under the lead sponsorship of Ghufran Dhari Awad.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient age 18-25.

  * Patient with moderate crowding in mandibular anterior region with Little Irrigularity Index (LII) 4-6 mm.
  * Indicated for fixed orthodontic appliance therapy (non-extraction treatment)
  * Healthy periodontium (probing depths ≤3 mm, gingival and plaque indices6 scores ≤ 1, bleeding on probing ≤ 10%).
  * Presence of all the mandibular permanent teeth, except the third molars.
  * The overbite and overjet should not impede bracket placement on the mandibular anterior teeth.

Exclusion Criteria:

Systemic diseases affecting bone (osteoporosis, endocrine disorders), kidney disease, hyperparathyroidism.

* Medications affecting bone metabolism (bisphosphonates, systemic steroids, Vitamin D3 supplements).
* Known allergy to study agents or local anesthetics.
* History of previous orthodontic intervention
* History of trauma or root resorption in the mandibular anterior teeth

Where it's running

• College of Dentistry, University of Baghdad
  Baghdad, Baghdad Governorate, Iraq Recruiting
• College of Dentistry, University of Baghdad
  Baghdad, Baghdad Governorate, Iraq Recruiting

Study contacts

• Study coordinator: Ghufran Dhari Awad, MSc. Orthodontics
• Email: ghufrandhari822@gmail.com
• Phone: +9647709644834

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Clear twin block for growing patients with class II malocclusion

  This study tests whether wearing a clear twin block appliance for 3 months helps correct dento-skeletal differences in kids aged 9–12 with Class II Division 1 malocclusion.

  Recruiting University of Baghdad · Baghdad, Baghdad Governorate · NCT07924982

• EHBM-based approach to boost collegians' oral health habits

  This study tests whether an Expanded Health Belief Model–based program can improve brushing, flossing, and dental visits among undergraduate students aged 18-25.

  Recruiting University of Baghdad · Basra, Basra Governorate · NCT07715773

• 3D printed reverse twin block to treat Class III malocclusion in growing kids

  This trial tests whether a 3D-printed reverse twin block can better correct maxillary deficiency in children with Class III alignment compared with the conventional appliance over six months.

  Recruiting University of Baghdad · Baghdad · NCT07710391

• Probiotics vs Zn/CHX Mouthwash for Halitosis and Plaque in Fixed Orthodontic Patients

  Aimed at seeing if probiotic lozenges or a zinc-chlorhexidine mouthwash can reduce bad breath and plaque in people with braces.

  Recruiting University of Baghdad · Baghdad, Alkargh · NCT07693972

• Direct 3D-printed vs thermoformed clear aligners in mild crowding

  This study tests whether in-office 3D-printed clear aligners work better than standard thermoformed aligners for teens and young adults with mild crowding or spacing.

  Recruiting at 3 sites University of Baghdad · Baghdad, Bab Al-Muadham and 2 other locations · NCT07637227

• Breathing Exercises After Open-Heart Surgery

  This trial tests whether segmental breathing or active cycle breathing technique help people who just had open-heart surgery feel less short of breath and improve their heart and lung function.

  Recruiting at 3 sites University of Baghdad · Baghdad, Baghdad Governorate and 2 other locations · NCT07591987

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.