A study to understand cancer prevention through lifestyle and genetics
Connect for Cancer Prevention Study: A Prospective Cohort Study Within Integrated Healthcare Systems in the US
National Institutes of Health Clinical Center (CC) · NCT04609072
This study is trying to find out how lifestyle and genetics affect cancer risk by collecting health information from 200,000 adults aged 30 to 70 who have never had cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200000 (estimated) |
| Ages | 30 Years to 70 Years |
| Sex | All |
| Sponsor | National Institutes of Health Clinical Center (CC) (nih) |
| Locations | 10 sites (Denver, Colorado and 9 other locations) |
| Trial ID | NCT04609072 on ClinicalTrials.gov |
What this trial studies
The Connect for Cancer Prevention Study aims to investigate the causes of cancer by collecting data on lifestyle, genetics, and health history from participants. This observational cohort study will enroll 200,000 adults aged 30 to 70 who have never had cancer, utilizing modern digital technologies to gather repeated exposure information and biological specimens. Participants will be followed over time to identify factors influencing cancer risk and to establish a biorepository for future research. The study seeks to create a comprehensive resource for understanding cancer etiology, early detection, and survivorship.
Who should consider this trial
Good fit: Ideal candidates are adults aged 30 to 70 who receive healthcare from participating systems and have never been diagnosed with invasive cancer.
Not a fit: Patients with a history of invasive cancer (other than non-melanoma skin cancer) or known cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new insights and strategies for cancer prevention, potentially reducing the incidence of cancer.
How similar studies have performed: Other studies have shown success in using similar observational approaches to understand cancer risk factors, making this study a continuation of established research methodologies.
Eligibility criteria
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: Due to the minimal risk nature of this protocol, all individuals interested and able to participate in Connect for Cancer Prevention, who meet the eligibility criteria at time of initial study invitation, will be able to participate. In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Patients or members of participating IHCS at the time of enrollment * Age between 30 and 70 years old at study invitation If an individual is determined to be ineligible at the time of enrollment due to age, the individual will be allowed to re-enroll at a later time once the recruit meets the age requirement. This includes recruits that did not meet the original age requirement of 40-65 years of age but now meet the updated age range of 30-70. EXCLUSION CRITERIA: An individual who meets any of the following criteria at time of initial study invitation will be excluded from participation in this study: * Individuals with a confirmed history of invasive cancer (other than non-melanoma skin cancer) * Individuals with known cognitive impairment documented in their medical record
Where this trial is running
Denver, Colorado and 9 other locations
- Kaiser Permanente Colorado — Denver, Colorado, United States (RECRUITING)
- Kaiser Permanente Georgia — Atlanta, Georgia, United States (RECRUITING)
- Kaiser Permanente Hawaii — Honolulu, Hawaii, United States (RECRUITING)
- University of Chicago Medical Center — Chicago, Illinois, United States (ACTIVE_NOT_RECRUITING)
- Henry Ford Health Systems — Detroit, Michigan, United States (RECRUITING)
- HealthPartners — Minneapolis, Minnesota, United States (RECRUITING)
- Kaiser Permanente Northwest — Portland, Oregon, United States (RECRUITING)
- Sanford Health — Sioux Falls, South Dakota, United States (RECRUITING)
- Baylor Scott and White Health — Dallas, Texas, United States (RECRUITING)
- Marshfield Clinic Health System — Marshfield, Wisconsin, United States (RECRUITING)
Study contacts
- Principal investigator: Nicolas A Wentzensen, M.D. — National Cancer Institute (NCI)
- Study coordinator: Nicolas A Wentzensen, M.D.
- Email: ConnectPI@nih.gov
- Phone: (866) 462-6621
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cancer, General Research Use, Risk Factors, medical conditions, Pathology, Blood, Urine, Natural History