3- vs 5-Needle Genicular Nerve Block for Knee Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two genicular nerve block techniques in adults with unilateral knee osteoarthritis who have had at least three months of non-surgical care. Participants are randomized to receive either a 3-needle blockade targeting the superior medial, superior lateral, and inferior medial nerves or a 5-needle blockade that adds additional sensory branches. Outcomes focus on pain and quality of life, with eligibility restricted to KOA patients meeting Kellgren-Lawrence grade 2 or higher and without confounding knee conditions. The trial is led by Tanta University and will be conducted at a single site in Tanta, Egypt. The goal is to determine if the broader 5-needle approach offers superior clinical benefit compared with the standard 3-needle technique.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years.
* Both sexes.
* Patients with unilateral chronic knee pain for more than 3 months.
* Patients received conservative treatment for at least 3 months.
* Diagnosed Knee osteoarthritis (KOA) according to the American College of Rheumatology (ACR) criteria, and grade greater than or equal to Kellgren-Lawrence grade 2.

Exclusion Criteria:

* Chronic knee pain is due to causes other than KOA, such as connective tissue diseases, lumbar radicular neuropathy (spondylolisthesis, spinal stenosis), or sciatic pain.
* Knee effusion.
* Neuro/psychiatric disorders.
* History of intra-articular injection in the prior 3 months.
* Prior knee surgery.
* Active systemic or local knee infections; anticoagulant use.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Mohammed S Elsharkawy, MD
• Email: mselsharkawy@med.tanta.edu.eg
• Phone: 00201148207870

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.