β2M Levels After Hemodialysis: Predicting Post-Dialysis Rebound
Official title: Predicting the Post-dialysis Rebound of β2-microglobulin
Run by East and North Hertfordshire NHS Trust · NCT07713680 · Data updated 2026-11-12
This study tests whether measuring blood levels of β2-microglobulin in people on long-term hemodialysis can help predict how much the protein reappears in the blood after dialysis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | East and North Hertfordshire NHS Trust Government |
| Locations | 1 site (Stevenage) |
| Status | Recruiting |
| Started | February 24, 2026 |
| Main results expected | November 2026 |
| Study ends | November 2026 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT07713680 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and older with end-stage renal disease on maintenance hemodialysis for at least 3 months who can provide informed consent.
✕Probably not a fit
Patients unable to consent or those with an acute infection within the past two weeks may not benefit from this observational assessment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study follows adults with end-stage renal disease who are on maintenance hemodialysis to observe β2-microglobulin blood concentrations. Researchers will measure levels before and after dialysis to understand how much rebound occurs between sessions. The goal is to see if post-dialysis rebound can be predicted based on initial concentrations and dialysis-related factors. No intervention is being tested; the study aims to characterize natural fluctuations to inform patient management. The investigation is conducted at East and North Hertfordshire NHS Trust in Stevenage, with data collection under standard care conditions.
Why it matters
Potential benefit: If successful, the findings could help clinicians anticipate β2-microglobulin rebound and tailor monitoring or care for dialysis patients.
How similar studies have gone: Previous research has documented β2-microglobulin dynamics in dialysis, supporting the relevance of studying post-dialysis rebound.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or above. * Ability to give informed consent. * End Stage Renal Disease established on maintenance haemodialysis for at least 3 months Exclusion Criteria: * Inability to give informed consent. * Acute infection in last 2 weeks.
Where it's running
-
East and North Hertfordshire NHS Trust
Stevenage, United Kingdom Recruiting
Study contacts
- Principal investigator: Shaza Adam — Lister Hospital, East and North Hertfordshire Teaching NHS Trust
- Study coordinator: Shaza Adam, Clinical research Fellow
- Email: Shaza.adam@nhs.net
- Phone: 00447365073834
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.