Cryotherapy to the back of the nose to ease runny nose symptoms
Official title: Cryotherapy to the Nose for Chronic Rhinitis: A Single Site, Pilot Study in Adults
Run by East and North Hertfordshire NHS Trust · NCT07917091 · Data updated 2026-11-12
This study tests whether a cold, in-clinic treatment can help adults with chronic rhinitis who continue to have watery noses despite standard care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | East and North Hertfordshire NHS Trust Government |
| Locations | 1 site (Stevenage) |
| Status | Recruiting |
| Started | October 14, 2025 |
| Main results expected | October 31, 2026 |
| Study ends | December 22, 2026 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT07917091 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with persistent rhinitis symptoms (congestion and/or rhinorrhea) despite appropriate medical therapy, seen at Lister Hospital ENT.
✕Probably not a fit
Patients with confirmed chronic rhinosinusitis, allergic rhinitis, cryoglobulinemia, certain cold-induced conditions, or active skin wounds near the target area may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational assessment will apply a single cryotherapy treatment to the posterior nasal nerves in adults with persistent chronic rhinitis at Lister Hospital. Participants will have two additional visits beyond routine care: the treatment visit and a 6-week follow-up, plus ongoing 3-month follow-ups. Patient-reported outcomes and procedure details such as duration and ease of administration will be collected to evaluate feasibility and potential benefit in an NHS outpatient setting. The study aims to inform whether a larger randomized trial is warranted and to characterize which patients might benefit most.
Why it matters
Potential benefit: If successful, patients could experience relief from watery nasal discharge and other rhinitis symptoms after a minimally invasive, in-clinic procedure.
How similar studies have gone: Cryotherapy for chronic rhinitis is an emerging approach; prior NICE guidance supports further investigation, but definitive results from large trials are still needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult patients presenting to the ENT Department at Lister Hospital with Rhinitis may be included. Symptoms may include nasal congestion and/or rhinorrhea with/without nasal itching and sneezing. Exclusion Criteria: * Confirmed CRS * Allergic Rhinitis * Cryoglobulinemia * paroxysmal cold hemoglobinuria * cold urticarial Raynaud's disease * open and/or infected wounds or other skin conditions at or near the target tissue
Where it's running
-
Lister Hospital
Stevenage, United Kingdom Recruiting
Study contacts
- Study coordinator: Joanna Stephens, MBChB FRCS (ORL-HNS)
- Email: jaonnastephens@nhs.net
- Phone: 01438 288019
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.