1:4 Reishi liquid extract for improving sleep quality

The Effects on Sleep Quality of 1:4 Reishi Liquid Extract

Not applicable Interventional Efforia, Inc · NCT07294482

This study will test whether taking 1 ml of a 1:4 Reishi mushroom liquid extract 30 minutes before bed helps adults in the U.S. sleep better and feel less stressed.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years and up
SexAll
SponsorEfforia, Inc Industry-sponsored
Locations1 site (New York, New York)
Trial IDNCT07294482 on ClinicalTrials.gov

What this trial studies

This is a remotely administered, decentralized interventional study testing daily use of a 1:4 Reishi liquid extract taken 30 minutes before bedtime. Participants will self-administer 1 ml of the tincture each night and report sleep metrics including duration, sleep onset latency, nighttime awakenings, and perceived restfulness, along with daytime energy and perceived stress. Data are collected remotely and participants receive individualized feedback on how the tincture affects their sleep patterns. The trial excludes people with certain medical conditions or medication use that could raise safety concerns and is open to English-reading U.S. residents who can follow the protocol.

Who should consider this trial

Good fit: Ideal candidates are adult U.S. residents who can read English, can follow the protocol, and do not meet exclusion criteria such as pregnancy, anticoagulant use, immunocompromise, liver disease, chronic illness, mental health disorders, or mushroom allergies.

Not a fit: Those who are pregnant or nursing, on blood thinners, immunocompromised, have liver disease, chronic illnesses, mental health disorders, or mushroom allergies are excluded and therefore unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, the Reishi tincture could modestly increase sleep duration, reduce nocturnal awakenings, and lower perceived stress for some users.

How similar studies have performed: There is limited preliminary and animal data and some small human reports suggesting calming or sleep-promoting effects of Reishi, but well-powered randomized human trials are lacking.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Can read and understand English.
* US resident.
* Willing and able to follow the requirements of the protocol.

Exclusion Criteria:

* Individuals with Allergies
* Pregnant or Nursing Women
* Individuals on Anticoagulants
* Immunocompromised Individuals
* Individuals with Liver Disease
* Children and Adolescents
* Individuals with Chronic Illnesses
* Those with Mental Health Disorders

Where this trial is running

New York, New York

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Sleep
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.