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Clinical trials and research at Vertex Pharmaceuticals Incorporated

• 12Clinical trials
• 19Countries

Newest trials

All recruiting trials (12)

• VX-407 pharmacokinetics after a single dose in adults with ADPKD

  This study tests how VX-407 is absorbed, distributed, metabolized, and excreted after a one-time oral dose in adults with polycystic kidney disease.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Lincoln, Nebraska · NCT07868926

• How VX-407 interacts with common birth control pills

  This study tests whether VX-407 affects how birth control pills work in people with ADPKD.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Montreal · NCT07792408

• VX-433 first‑in‑human safety and PK study in healthy volunteers

  This study tests the safety, how VX-433 behaves in the body, and possible drug interactions in healthy adults, to see if it’s suitable for people with narcolepsy type 1 in the future.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Salt Lake City, Utah · NCT07584434

• VX-272 dose escalation in healthy adults

  This will test single and multiple increasing doses of the experimental drug VX-272 in healthy adults to see how safe it is and how the body handles it.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Tempe, Arizona · NCT07437105

• Dose escalation of VX-581 to check safety and drug levels in healthy adults

  The trial will test increasing doses of VX-581 in healthy adults to see if it is safe and to measure how the body absorbs and clears the drug.

  Recruiting Phase 1 Vertex Pharmaceuticals Incorporated · Overland Park, Kansas · NCT07283770

• Suzetrigine for pain from diabetic peripheral neuropathy

  This trial will test whether Suzetrigine reduces pain in adults with diabetic peripheral neuropathy.

  Recruiting at 70 sites Phase 3 Vertex Pharmaceuticals Incorporated · Birmingham, Alabama and 74 other locations · NCT07231419

• Povetacicept for people with primary membranous nephropathy

  This trial tests whether povetacicept is safe and helps people with primary membranous nephropathy, with tacrolimus listed as an intervention in the protocol.

  Recruiting at 116 sites Phase 2/3 Vertex Pharmaceuticals Incorporated · Montgomery, Alabama and 116 other locations · NCT07204275

• Evaluating VX-880 for Type 1 Diabetes in Kidney Transplant Patients

  This study is testing if a new treatment called VX-880 can help people with Type 1 Diabetes who have had a kidney transplant manage their blood sugar better.

  Recruiting at 7 sites Phase 3 Vertex Pharmaceuticals Incorporated · Philadelphia, Pennsylvania and 6 other locations · NCT06832410

• Evaluating Suzetrigine for Pain from Diabetic Peripheral Neuropathy

  This study is testing if a new medication called Suzetrigine can help people with diabetic nerve pain feel better compared to a placebo and a standard treatment.

  Recruiting at 58 sites Phase 3 Vertex Pharmaceuticals Incorporated · Anniston, Alabama and 75 other locations · NCT06628908

• Evaluating VX-993 for pain from diabetic nerve damage

  This study is testing if a new medication called VX-993 can help people with diabetes who have been dealing with pain in their legs and feet from nerve damage feel better compared to a standard treatment and a placebo.

  Recruiting at 22 sites Phase 2 Vertex Pharmaceuticals Incorporated · Cullman, Alabama and 46 other locations · NCT06619860

• Evaluating a single dose of CTX001 for treating transfusion-dependent beta-thalassemia and severe sickle cell disease

  This study is testing a single dose of a new treatment called CTX001 to see if it can help people with transfusion-dependent beta-thalassemia or severe sickle cell disease feel better.

  Recruiting at 6 sites Phase 3 Vertex Pharmaceuticals Incorporated · New York, New York and 5 other locations · NCT05477563

• Evaluating VX-880 for Type 1 Diabetes with Severe Hypoglycemia

  This study is testing if a new treatment called VX-880 can help people with Type 1 diabetes who have trouble sensing low blood sugar and have had severe low blood sugar episodes.

  Recruiting at 26 sites Phase 3 Vertex Pharmaceuticals Incorporated · Duarte, California and 28 other locations · NCT04786262

Quick answers

How many clinical trials run by Vertex Pharmaceuticals Incorporated are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (11 trials), Canada (4 trials), Germany (4 trials), Italy (4 trials), United Kingdom (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 1: 5, Phase 2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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