Evaluating VX-880 for Type 1 Diabetes in Kidney Transplant Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the efficacy, safety, and tolerability of VX-880 in individuals with Type 1 Diabetes who have undergone a kidney transplant. Participants must have a history of insulin dependence for at least five years and be on a stable immunosuppression regimen. The study will involve the use of continuous glucose monitoring to track participants' glucose levels throughout the trial. The goal is to determine how well VX-880 can manage diabetes in this specific patient population.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

* Clinical history of T1D with greater than or equal to (≥)5 years of insulin dependence
* Taking a stable immunosuppression regimen of tacrolimus and mycophenolate mofetil, mycophenolate sodium, or sirolimus for at least 4 weeks
* Consistent use of continuous glucose monitor (CGM) for at least 4 weeks before Screening and willingness to use CGM for the duration of the study

Key Exclusion Criteria:

* Prior islet cell transplant, organ transplant (other than kidney transplant), or cell therapy, except prior pancreatic graft that failed within the first 4 weeks
* Participants had \>1 kidney transplant procedure

Other protocol defined Inclusion/Exclusion criteria may apply.

Where it's running

• Perelman Center for Advanced Medicine - Endocrinology
  Philadelphia, Pennsylvania, United States Recruiting
• Montefiore Clinical and Translational Research Center - Endocrinology
  Pittsburgh, Pennsylvania, United States Recruiting
• UW University Hospital - Endocrinology
  Madison, Wisconsin, United States Recruiting
• Toronto General Hospital - Endocrinology
  Toronto, Canada Recruiting
• Vancouver General Hospital - Gordon and Leslie Diamond Health Care Centre
  Vancouver, Canada Recruiting
• King Abdullah International Medical Research Center (KAIMRC) - Riyadh - Endocrinology
  Riyadh, Saudi Arabia Recruiting

Study contacts

• Study coordinator: Medical Information
• Email: medicalinfo@vrtx.com
• Phone: 617-341-6777

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.