Sponsor or institution
Clinical trials and research at University of Puerto Rico Med Sciences
As of November 12, 2026, Find a Trial lists 114 NIH-funded research projects at this institution, with $66.9 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 114NIH research projects
NIH-funded research (newest 40 of 114)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Proteins in brain-supporting cell vesicles linked to HIV-related cognitive issues
A study from the University of Puerto Rico investigates proteins in brain-cell vesicles found in blood and CSF to understand HIV-related cognitive impairment better.
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Blood-vessel mitochondria and brain inflammation in Alzheimer's disease
This work looks at how tiny powerhouses inside blood‑vessel cells may trigger inflammation that worsens Alzheimer's for people with the disease.
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Fh15-based therapy to calm inflammation in sepsis and ulcerative colitis
A research project tests a molecule from a parasitic organism (Fh15) to reduce harmful inflammation in adults with sepsis or ulcerative colitis.
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p(UG) RNA Quadruplexes and ALS: How RNA shapes stress granules and TDP-43 pathology
Aimed at people with ALS, this grant tests how a specific RNA shape helps stress granules form and how that affects disease-related TDP-43 changes.
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Tech-enabled Aids to Help Older Adults Stay Independent
A 3-year program tests a low-cost, group-based assistive technology approach to help adults 65+ stay independent by improving daily activities and quality of life in primary care clinics.
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Clinical and Technology Resources Core expands access to clinical research facilities and technology across Alliance institutions
A multi-institutional core will provide researchers with access to clinical trial units, cutting-edge tech, facilities, and training to advance patient-focused clinical research.
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Health Research Core to Grow clinical trials and investigator work in Puerto Rico
This grant funds a Health Research Core to help doctors and researchers in Puerto Rico run more clinical trials and studies that could improve health for people on the island and in the US mainland.
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Professional Development for Clinicians and Researchers in Puerto Rico
A program designed to boost skills, mentorship, and career growth for researchers in Puerto Rico to advance clinical and translational research.
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Community Engagement and Outreach Core for population-driven health research
This grant funds a Community Engagement and Outreach Core to connect researchers with Puerto Rico communities, helping research focus on real health needs and improve outcomes.
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RDCD Core supports better clinical and translational research through design, data management, and compliance
A core support program helps researchers design smarter studies, manage real-world data, and ensure ethical conduct to advance patient-centered clinical research.
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Administrative Core to Accelerate Clinical and Translational Research in Puerto Rico
A grant to strengthen administration and coordination of clinical and translational research in Puerto Rico to speed discoveries that help people with prevalent health conditions.
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Alliance for Clinical and Translational Research in Puerto Rico
A large, island-wide effort in Puerto Rico to speed up practical medical research that can prevent and treat common health problems and improve healthcare in communities.
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New medicines to stop cancer from spreading
Researchers are developing improved versions of a drug that aim to block cancer cells from spreading in people with pancreatic and breast cancers using lab models and short-term tests on patient tumor tissue.
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Research Capacity Core supports advanced data and imaging for AIDS-related research
A core grant helps the University of Puerto Rico Medical Sciences Campus integrate genomics, proteomics, imaging, and data science to accelerate research on AIDS and other infectious diseases.
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Community Engagement Core for Health Equity in Puerto Rico
A national-level grant supports a Community Engagement Core to help researchers work better with Puerto Rican communities to reduce health disparities.
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Investigator Development Core to Grow Independent Researchers
A program to mentor junior researchers at the University of Puerto Rico Medical Sciences Campus and provide funds to pilot projects that could lead to independent funding.
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Improving PrEP Uptake for Latino MSM in Puerto Rico
A U.S. NIH grant tests the best way to increase PrEP use among Latino men who have sex with men in Puerto Rico to help prevent HIV infections.
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Microbiome factors linked to persistent hr-HPV and cervical cancer risk
Researchers are studying how the vaginal microbiome and other host factors influence the persistence of high-risk HPV and the risk of cervical cancer, with a focus on populations in Latin America and the Caribbean.
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Center for Collaborative Research in Health Disparities Administrative Core
This grant funds a coordinating center to strengthen partnerships, mentorship, and governance for health disparities research at the University of Puerto Rico and partners.
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Center for Collaborative Research in Health Disparities
A national health-disparities research center at the University of Puerto Rico helps scientists work together to study and reduce health differences affecting Puerto Rican communities.
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MHC typing to support diverse macaque colonies for AIDS and infectious disease research
A specialized core will keep a genetically diverse group of Indian-origin rhesus macaques for AIDS-related and other infectious or autoimmune disease studies, using detailed MHC typing to help researchers choose the right animals.
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Maintaining a Special Primate Colony for AIDS-related Research
A research grant aims to keep a carefully screened rhesus macaque colony healthy and ready to support AIDS-focused scientific studies.
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Maintaining a Special Pathogen Free Primate Colony for AIDS/HIV research
A program to keep a colony of carefully screened monkeys ready for AIDS/HIV research, with ongoing health checks and genetic management.
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Understanding end-of-life care quality for cancer patients in Puerto Rico
This grant explores what shapes the quality of end-of-life care for people with cancer in the US and Puerto Rico to help ensure care aligns with patients’ needs and values.
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Cancer bioinformatics and biostatistics hub to support researchers
A cancer-focused bioinformatics and biostatistics core will provide a hub of expert support to improve study design, data analysis, and training for researchers at the University of Puerto Rico Medical Sciences campus.
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Administrative Core to Accelerate Cancer Research at CePCHe
A centralized administrative core helps cancer researchers, including new scientists, manage projects more efficiently and move promising ideas toward independent funding.
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CePCHe: A national center to advance cancer prevention and care through research and training
A national cancer research center at the University of Puerto Rico aims to accelerate science, train researchers, and translate findings into better prevention and care for people affected by advanced cancers.
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Using AI and drug modeling to understand why genes and other medicines change clopidogrel response
This project uses AI, genetic data, and drug-response models to find why people with different genes or taking other medications respond differently to clopidogrel.
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Understanding Brain Changes in Cocaine Addiction
This research explores how cocaine changes specific brain cells to better understand why addiction happens.
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Seahorse XF Pro Analyzer for metabolic profiling in cancer, cardiovascular disease, and education
A powerful instrument will be purchased to study cellular energy and mitochondria in cancer and heart disease, helping researchers and students at the University of Puerto Rico Medical Sciences Campus.
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Neuronal circuits in approach-avoidance conflict in mice
Researchers are studying how brain circuits that drive attraction and avoidance interact during conflict, using mice to understand anxiety, depression, and addiction better.
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BASIS FOR biomedical infrastructure and training in Puerto Rico
This grant helps two Puerto Rico colleges expand data science training and cell culture facilities to boost biomedical research and workforce development.
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Data Science Core supports big data, AI, and bioinformatics across PR-INBRE
A hub for data science and AI tools to help Puerto Rico researchers work with big biomedical data and collaborate more effectively.
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Centralized Instrumentation Cores to boost Puerto Rico biomedical research
A grant provides shared, advanced lab instruments and expert support to researchers in Puerto Rico to accelerate biomedical discoveries.
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Administrative Core supports biomedical research capacity and training in Puerto Rico INBRE
This grant provides leadership and coordination to boost biomedical research training and collaboration across Puerto Rico institutions.
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PR INBRE: Advancing Biomedical Research in Puerto Rico
A large NIH program renews support to build research capacity and train scientists in Puerto Rico, strengthening facilities, mentorship, and collaboration across multiple institutions.
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Antibiotics, mouth microbes, and immune changes in throat (oropharyngeal) cancer
This project looks at whether taking antibiotics changes mouth bacteria and immune responses in people with HPV-related oropharyngeal (throat) cancer and in HPV-positive women.
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New small-molecule drugs to block Rac and Cdc42 and stop cancer spread
Testing new small-molecule drugs that block Rac and Cdc42 proteins to try to stop cancer cells from spreading, aiming to help people with metastatic breast cancer.
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Does a bacterial protein called USP harm the gut and trigger immune responses?
This project tests whether a bacterial protein called USP can damage human gut tissue and cause an antibody response using lab-grown gut cells and patient samples.
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Establishing a consortium to enhance health equity for Hispanic Puerto Ricans
This study is all about listening to Hispanic Puerto Ricans to understand their experiences and needs with FDA-approved medications, so we can work together to improve their health and make sure everyone gets the care they deserve.
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