NIH-funded research R01 grant

Site-based social network approach to find undiagnosed HIV, boost testing among men, and reduce stigma in South Africa

Official title: Site-randomized Trial of a Novel Social Network Recruitment Intervention to Locate More Undiagnosed Positive Cases of HIV, Increase HIV Testing among Men, and Reduce HIV-related Stigma in South Africa

Funded at University of Illinois at Chicago · NIH-11519066 · Data updated 2026-11-12

A new approach uses people with HIV to recruit a broader circle for HIV testing in South Africa, aiming to find undiagnosed cases, increase testing among men, and lower stigma.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Illinois at Chicago
NIH-funded
Lab location1 site (Chicago, UNITED STATES)
Project startJuly 15, 2024
Project endApril 30, 2029
Funding year2026
Award (this year)$350,126
NIH project number3R01MH136871-03S1
Project IDNIH-11519066 on NIH RePORTER

Who could benefit from this research

Could help

Adults in South Africa who are at risk or unaware of their HIV status, including men who are less likely to get tested.

Less likely to help

Individuals not connected to the targeted networks or outside the study sites may not experience direct benefits.

What this research studies

This project tests a social network recruitment strategy implemented at select sites in South Africa to reach men who may not seek HIV testing. Newly diagnosed individuals will help recruit their wider networks to get tested and linked to care if positive or to repeat testing if negative, with a focus on reducing stigma. The study will compare how well this expanded, peer-driven recruitment works in getting more people tested and engaged in treatment compared with traditional methods. The goal is to locate undiagnosed cases, cut HIV transmission, and improve access to care for those affected. Community and participant safety, confidentiality, and ethical engagement will be central throughout the intervention.

Why it matters

Potential benefit: If successful, more people will learn their HIV status sooner and be linked to care, potentially reducing transmission and improving health outcomes.

How similar studies have gone: Previous peer-led recruitment approaches have shown promise in increasing HIV testing, with this study expanding to non-risk networks to reduce stigma.

Where this research is happening

  • University of Illinois at Chicago
    Chicago, United States
    Active

Researchers

  • Principal investigator: Williams, Leslie Denise — University of Illinois at Chicago
  • Study coordinator: Williams, Leslie Denise

Related research

Other NIH-funded projects on the same topics.

  • MSC Secretome Eye Drops to Speed Healing of Corneal Wounds

    A new eye drop made from stem cell–secreted factors is being tested to help adults with non-healing corneal wounds recover vision faster.

    NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11628932

  • UIC Center for Healthy Work

    A national program led by UIC aims to improve the health and well-being of workers through collaborative research and practical solutions.

    NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11623427

  • Coordinated Oral Health Promotion for Chicago Kids

    A long-running study in Chicago is following children and their caregivers to find ways to reduce tooth decay and improve daily life for families.

    NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11614800

  • Targeting p38 MAPK to slow ALS-related axonal damage

    Aims to block a specific brain-wide signaling pathway (p38 MAPK) to reduce nerve damage in people with various genetic forms of ALS.

    NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11607932

  • Precision nanomedicine to calm inflammation and protect bone in gum disease

    A new, targeted nanomedicine approach aims to reduce gum inflammation and prevent bone loss in adults with periodontal disease.

    NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11607783

  • Role of DPP in Dental Pulp Stem Cells and their Regenerative Potential

    A project explores how a natural tooth protein helps dental pulp stem cells repair and regenerate the tooth’s inner tissue.

    NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11607777

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.